Biological ActivityNMDA receptor partial agonist that acts at the glycine site. Simultaneously acts as a promoter of the induction of long-term potentiation (LTP) and as a suppressor of long-term depression (LTD). Exhibits nootropic, neuroprotective and antinociceptive activity, and enhances learning, memory and cognition in vivo. Brain penetrant.
(Modifications: Thr-4 = C-terminal amide)
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GLYX-13: A monoclonal antibody-derived peptide that acts as an N-MthD.-aspartate receptor modulator.
Moskal et al.
Antinociceptive action of GLYX-13: a N-MthD.-aspartate receptor glycine site partial agonist.
Wood et al.
The N-MthD.-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats.
Burgdorf et al.
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