Catalog Number: 3406
Biological Activity
NMDA receptor partial agonist that acts at the glycine site. Simultaneously acts as a promoter of the induction of long-term potentiation (LTP) and as a suppressor of long-term depression (LTD). Exhibits nootropic, neuroprotective and antinociceptive activity, and enhances learning, memory and cognition in vivo. Brain penetrant.
Technical Data
  • M.Wt:
    413.47
  • Formula:
    C18H31N5O6
  • Sequence:
    TPPT

    (Modifications: Thr-4 = C-terminal amide)

  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    117928-94-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The N-methyl-D-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats.
    Burgdorf et al.
    Neurobiol.Aging, 2009;32:698
  2. GLYX-13: A monoclonal antibody-derived peptide that acts as an N-methyl-D-aspartate receptor modulator.
    Moskal et al.
    Neuropharmacology, 2005;49:1077
  3. A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral-CA1 synapses in hippocampus.
    Zhang et al.
    , 2008;55:1238
  4. Antinociceptive action of GLYX-13: a N-methyl-D-aspartate receptor glycine site partial agonist.
    Wood et al.
    Neuroreport., 2008;19:1059

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