Catalog Number: 2285
Alternate Names: Goe 6983
Chemical Name: 3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Biological Activity
Broad spectrum protein kinase C (PKC) inhibitor (IC50 values are 7, 7, 6, 10, 60 and 20000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ and PKCμ respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. Optimizes naïve human pluripotent stem cell growth and viability following naïve cell derivation from primed ESCs and iPSCs using naïve human stem cell medium (NHSM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibition of protein kinase C μ by various inhibitors. Differentiation from protein kinase c isozymes.
    Gschwendt et al.
    FEBS Lett., 1996;392:77
  2. Go 6983 exerts cardioprotective effects in myocardial ischemic/reperfusion.
    Peterman et al.
    J.Cardiovasc.Pharmacol., 2004;43:645
  3. Go 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury.
    Young et al.
    Cardiovasc.Drug Rev., 2005;23:255
  4. Derivation of novel human ground state naive pluripotent stem cells.
    Gafni et al.
    Nature, 2013;504:282

The citations listed below are publications that use Tocris products. Selected citations for Go 6983 include:

Showing Results 1 - 10 of 14

  1. CD24 tracks divergent pluripotent states in mouse and human cells.
    Authors: Shakiba Et al.
    J Biol Chem
  2. Phrenic long-term facilitation requires PKCθ activity within phrenic motor neurons.
    Authors: Devinney Et al.
    Proc Natl Acad Sci U S A
  3. Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38.
    Authors: Toda and Huganir
    Nat Commun
  4. Ets and GATA Transcription Factors Play a Critical Role in PMA-Mediated Repression of the ckβ Promoter via the Protein Kinase C Signaling Pathway.
    Authors: Kuan Et al.
    Biol Chem
  5. NMDA modulates oligodendrocyte differentiation of subventricular zone cells through PKC activation.
    Authors: Cavaliere Et al.
    Cell Signal
  6. Systematic analysis of bacterial effector-postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domain interactions demonstrates Shigella OspE protein promotes protein kinase C activation via PDLIM proteins.
    Authors: Yi Et al.
  7. Protein kinase C-dependent signaling controls the midgut epithelial barrier to malaria parasite infection in anopheline mosquitoes.
    Authors: Pakpour Et al.
    PLoS One
  8. GLI activation by atypical protein kinase C Ι/λ regulates the growth of basal cell carcinomas.
    Authors: Atwood Et al.
    J Neurosci
  9. Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL).
    Authors: Vliet Et al.
    J Biol Chem
  10. Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency.
    Authors: Rajendran Et al.
    J Biol Chem
  11. γ-protocadherins control cortical dendrite arborization by regulating the activity of a FAK/PKC/MARCKS signaling pathway.
    Authors: Garrett Et al.
    PLoS One
  12. Kallikrein 6 is a novel molecular trigger of reactive astrogliosis.
    Authors: Scarisbrick Et al.
    Front Cell Neurosci
  13. Angiotensin II mediates cell survival through upregulation and activation of the serum and glucocorticoid inducible kinase 1.
    Authors: Baskin and Sayeski
    BMC Complement Altern Med
  14. Self-renewal versus lineage commitment of embryonic stem cells: protein kinase C signaling shifts the balance.
    Authors: Dutta Et al.
    Stem Cells
Expand to show all
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