Broad spectrum protein kinase C (PKC) inhibitor (IC50
values are 7, 7, 6, 10, 60 and 20000 nM for PKCα
respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. Optimizes naïve human pluripotent stem cell growth and viability following naïve cell derivation from primed ESCs and iPSCs using naïve human stem cell medium (NHSM).
Soluble to 50 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Inhibition of protein kinase C μ by various inhibitors. Differentiation from protein kinase c isozymes.
Gschwendt et al.
FEBS Lett., 1996;392:77
Go 6983 exerts cardioprotective effects in myocardial ischemic/reperfusion.
Peterman et al.
Go 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury.
Young et al.
Cardiovasc.Drug Rev., 2005;23:255
Derivation of novel human ground state naive pluripotent stem cells.
Gafni et al.
The citations listed below are publications that use Tocris products. Selected citations for Go 6983 include:
Showing Results 1 - 10 of 14