Chemical Name: 3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Biological ActivityGo 6983 is a broad spectrum protein kinase C (PKC) inhibitor (IC50 values are 7, 7, 6, 10, 60 and 20000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ and PKCμ respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. Optimizes naïve human pluripotent stem cell growth and viability following naïve cell derivation from primed ESCs and iPSCs using naïve human stem cell medium (NHSM).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Derivation of novel human ground state naive pluripotent stem cells.
Gafni O, Weinberger L, Mansour AA et al.
Inhibition of protein kinase C μ by various inhibitors. Differentiation from protein kinase c isozymes.
Gschwendt et al.
FEBS Lett., 1996;392:77
Go 6983 exerts cardioprotective effects in myocardial ischemic/reperfusion.
Peterman et al.
Go 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury.
Young et al.
Cardiovasc.Drug Rev., 2005;23:255
Citations for Go 6983
The citations listed below are publications that use Tocris products. Selected citations for Go 6983 include:
25 Citations: Showing 1 - 10
Multiple sources of signal amplification within the B-cell Ras/MAPK pathway.
Authors: Mclaurin and Weiner
Mol Biol Cell 2019;30:1610
Transcriptional Heterogeneity in Naive and Primed Human Pluripotent Stem Cells at Single-Cell Resolution.
Authors: Messmer Et al.
Cell Rep 2019;26:815
Capacitation of human na�ve pluripotent stem cells for multi-lineage differentiation.
Authors: Rostovskaya Et al.
A distinct isoform of ZNF207 controls self-renewal and pluripotency of human embryonic stem cells.
Authors: Fang Et al.
Nat Commun 2018;9:4384
Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish.
Authors: Liu Et al.
Transl Psychiatry 2018;8:232
PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5.
Authors: Schaffer Et al.
Cell Rep 2018;25:2470
CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons.
Protein kinase D at the Golgi controls NLRP3 inflammasome activation.
Authors: Zhang Et al.
J Exp Med 2017;214:2671
Reduced ins. signaling maintains electrical transmission in a neural circuit in aging flies.
Authors: Augustin Et al.
PLoS Biol 2017;15:e2001655
AP-1 Transcription Factors Mediate BDNF-Positive Feedback Loop in Cortical Neurons.
Authors: Tuvikene Et al.
J Neurosci 2016;36:1290
Progesterone receptor membrane component-1 regulates hepcidin biosynthesis.
Authors: Li Et al.
J Clin Invest 2016;126:389
CD24 tracks divergent pluripotent states in mouse and human cells.
Authors: Shakiba Et al.
J Biol Chem 2015;6:7329
Phrenic long-term facilitation requires PKCθ activity within phrenic motor neurons.
Authors: Devinney Et al.
Proc Natl Acad Sci U S A 2015;35:8107
Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38.
Authors: Toda and Huganir
Nat Commun 2015;112:6712
Ets and GATA Transcription Factors Play a Critical Role in PMA-Mediated Repression of the ckβ Promoter via the Protein Kinase C Signaling Pathway.
Authors: Kuan Et al.
Biol Chem 2014;9:e113485
NMDA modulates oligodendrocyte differentiation of subventricular zone cells through PKC activation.
Authors: Cavaliere Et al.
Cell Signal 2014;7:261
Systematic analysis of bacterial effector-postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domain interactions demonstrates Shigella OspE protein promotes protein kinase C activation via PDLIM proteins.
Authors: Yi Et al.
Protein kinase C-dependent signaling controls the midgut epithelial barrier to malaria parasite infection in anopheline mosquitoes.
Authors: Pakpour Et al.
PLoS One 2013;8:e76535
GLI activation by atypical protein kinase C Ι/λ regulates the growth of basal cell carcinomas.
Authors: Atwood Et al.
J Neurosci 2013;494:484
Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL).
Authors: Vliet Et al.
J Biol Chem 2013;288:27519
Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency.
Authors: Rajendran Et al.
J Biol Chem 2013;288:24351
γ-protocadherins control cortical dendrite arborization by regulating the activity of a FAK/PKC/MARCKS signaling pathway.
Authors: Garrett Et al.
PLoS One 2012;74:269
Kallikrein 6 is a novel molecular trigger of reactive astrogliosis.
Authors: Scarisbrick Et al.
Front Cell Neurosci 2012;393:355
Angiotensin II mediates cell survival through upregulation and activation of the serum and glucocorticoid inducible kinase 1.
Authors: Baskin and Sayeski
BMC Complement Altern Med 2012;24:435
Self-renewal versus lineage commitment of embryonic stem cells: protein kinase C signaling shifts the balance.
Authors: Dutta Et al.
Stem Cells 2011;29:618
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Human osteosarcoma cells were incubated with 20 μM Go 6983 for 30 min prior to treatment with 10 μM LPA to estimate COX-2 expression using Western blot analysis. Go 6983 abolished LPA-induced COX-2 expression.
Used for the culture of naive human pluripotent stem cells in t2iL+go media. Go 6983 used at 2µM concentration.