Go 6983

  ( 15 citations )    
Product Datasheet
Catalog Number:2285
Alternate Names:Goe 6983
Chemical Name:3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Product Details
Citations (15)
Reviews
Biological Activity
Broad spectrum protein kinase C (PKC) inhibitor (IC50 values are 7, 7, 6, 10, 60 and 20000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ and PKCμ respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. Optimizes naïve human pluripotent stem cell growth and viability following naïve cell derivation from primed ESCs and iPSCs using naïve human stem cell medium (NHSM).
Technical Data
  • M.Wt:
    442.51
  • Formula:
    C26H26N4O3
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    133053-19-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Go 6983 include:

15 Citations: Showing 1 - 10
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  1. AP-1 Transcription Factors Mediate BDNF-Positive Feedback Loop in Cortical Neurons.
    Authors: Tuvikene Et al.
    J Neurosci  2016;36:1290
  2. CD24 tracks divergent pluripotent states in mouse and human cells.
    Authors: Shakiba Et al.
    J Biol Chem  2015;6:7329
  3. Phrenic long-term facilitation requires PKCθ activity within phrenic motor neurons.
    Authors: Devinney Et al.
    Proc Natl Acad Sci U S A  2015;35:8107
  4. Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38.
    Authors: Toda and Huganir
    Nat Commun  2015;112:6712
  5. Ets and GATA Transcription Factors Play a Critical Role in PMA-Mediated Repression of the ckβ Promoter via the Protein Kinase C Signaling Pathway.
    Authors: Kuan Et al.
    Biol Chem  2014;9:e113485
  6. NMDA modulates oligodendrocyte differentiation of subventricular zone cells through PKC activation.
    Authors: Cavaliere Et al.
    Cell Signal  2014;7:261
  7. Systematic analysis of bacterial effector-postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domain interactions demonstrates Shigella OspE protein promotes protein kinase C activation via PDLIM proteins.
    Authors: Yi Et al.
    Neuron  2014;289:30101
  8. Protein kinase C-dependent signaling controls the midgut epithelial barrier to malaria parasite infection in anopheline mosquitoes.
    Authors: Pakpour Et al.
    PLoS One  2013;8:e76535
  9. GLI activation by atypical protein kinase C Ι/λ regulates the growth of basal cell carcinomas.
    Authors: Atwood Et al.
    J Neurosci  2013;494:484
  10. Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL).
    Authors: Vliet Et al.
    J Biol Chem  2013;288:27519
  11. Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency.
    Authors: Rajendran Et al.
    J Biol Chem  2013;288:24351
  12. γ-protocadherins control cortical dendrite arborization by regulating the activity of a FAK/PKC/MARCKS signaling pathway.
    Authors: Garrett Et al.
    PLoS One  2012;74:269
  13. Kallikrein 6 is a novel molecular trigger of reactive astrogliosis.
    Authors: Scarisbrick Et al.
    Front Cell Neurosci  2012;393:355
  14. Angiotensin II mediates cell survival through upregulation and activation of the serum and glucocorticoid inducible kinase 1.
    Authors: Baskin and Sayeski
    BMC Complement Altern Med  2012;24:435
  15. Self-renewal versus lineage commitment of embryonic stem cells: protein kinase C signaling shifts the balance.
    Authors: Dutta Et al.
    Stem Cells  2011;29:618
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