GR 135531

  ( 5 citations )    
Product Datasheet
Catalog Number:0896
Alternate Names:5-MCA-NAT
Chemical Name:5-Methoxycarbonylamino-N-acetyltryptamine
Product Details
Citations (5)
Reviews
Biological Activity
Binds with high affinity to MT3 melatonin sites in hamster brain, and low affinity (and no efficacy) at MT1 and MT2 melatonin receptors and thus can be used to discriminate between the melatonin receptor subtypes.
Technical Data
  • M.Wt:
    275.31
  • Formula:
    C14H17N3O3
  • Solubility:
    Soluble to 100 mM in ethanol
  • Purity:
    >97
  • Storage:
    Store at RT
  • CAS No:
    190277-13-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for GR 135531 include:

5 Citations: Showing 1 - 5
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  1. Diadenosine tetraphosphate induces tight junction disassembly thus increasing corneal epithelial permeability.
    Authors: Loma Et al.
    J Neurosci  2015;172:1045
  2. Melatonin and its analog 5-methoxycarbonylamino-N-acetyltryptamine potentiate adrenergic receptor-mediated ocular hypotensive effects in rabbits: significance for combination therapy in glaucoma.
    Authors: Crooke Et al.
    J Pharmacol Exp Ther  2013;346:138
  3. MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries.
    Authors: Tunstall Et al.
    Br J Pharmacol  2011;336:127
  4. Melatonin inhibits tachykinin NK2 receptor-triggered 5-HT release from guinea pig isolated colonic mucosa.
    Authors: Kojima Et al.
    Br J Pharmacol  2011;162:1179
  5. Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion.
    Authors: Sjöblom Et al.
    J Pharmacol Exp Ther  2001;108:625

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