Catalog Number: 1788
Alternate Names: Gastrin-releasing peptide (porcine)
Biological Activity
Mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice in vivo. Also involved in mitogenesis, and GI tract and appetite regulation.
Technical Data
  • M.Wt:
    2805.31
  • Formula:
    C126H198N38O31S2
  • Sequence:
    APVSVGGGTVLAKMYPRGNHWAVGHLM

    (Modifications: Met-27 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    74815-57-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Neurobiology: Fear thou not.
    Dudai
    Nature, 2003;421:325
  2. Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear.
    Shumyatsky et al.
    Cell, 2002;111:905
  3. Gastrin-releasing peptide is a transmitter mediating porcine gallbladder contraction.
    Schjoldager et al.
    Am.J.Physiol., 1991;260:G577
  4. Bombesin receptors in the brain.
    Woodruff et al.
    Ann.N.Y.Acad.Sci., 1996;780:223

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