GRP (porcine)
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Description: Endogenous GRP receptor agonist
Alternative Names: Gastrin-releasing peptide (porcine)
Biological Activity
GRP (porcine) is a mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice in vivo. Also involved in mitogenesis, and GI tract and appetite regulation.Technical Data
M.Wt:
2805.31
Formula:
C126H198N38O31S2
Sequence:
APVSVGGGTVLAKMYPRGNHWAVGHLM
(Modifications: Met-27 = C-terminal amide)
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
74815-57-9
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Neurobiology: Fear thou not.
Dudai
Nature, 2003;421:325 -
Gastrin-releasing peptide is a transmitter mediating porcine gallbladder contraction.
Schjoldager et al.
Am.J.Physiol., 1991;260:G577 -
Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear.
Shumyatsky et al.
Cell, 2002;111:905 -
Bombesin receptors in the brain.
Woodruff et al.
Ann.N.Y.Acad.Sci., 1996;780:223
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