Biological ActivityGRP (porcine) is a mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice in vivo. Also involved in mitogenesis, and GI tract and appetite regulation.
(Modifications: Met-27 = C-terminal amide)
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Neurobiology: Fear thou not.
Gastrin-releasing peptide is a transmitter mediating porcine gallbladder contraction.
Schjoldager et al.
Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear.
Shumyatsky et al.
Bombesin receptors in the brain.
Woodruff et al.
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