Potent inhibitor of MET, VEGFR2, Ron and AXL (IC50
values are 0.4, 0.9, 3 and 11 nM, respectively). Also potently inhibits Tie-2, Flt-1, Flt-3, Flt-4, KIT, PDGFRα
. Inhibits migration and invasion of B16F10 melanoma cells in vitro
. Suppresses B16F10 tumor growth and metastasis in mice. Orally available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
AXL inhibitors in cancer: A medicinal chemistry perspective.
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Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma.
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