GSK 1363089 (CAS 849217-64-7): R&D Systems
Catalog Number: 6056
Alternate Names: XL 880, EXEL 2880, Foretinib
Chemical Name: N-[3-Fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
Biological Activity
Potent inhibitor of MET, VEGFR2, Ron and AXL (IC50 values are 0.4, 0.9, 3 and 11 nM, respectively). Also potently inhibits Tie-2, Flt-1, Flt-3, Flt-4, KIT, PDGFRα and PDGFRβ. Inhibits migration and invasion of B16F10 melanoma cells in vitro. Suppresses B16F10 tumor growth and metastasis in mice. Orally available.
Technical Data
  • M.Wt:
    632.65
  • Formula:
    C34H34F2N4O6
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    849217-64-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. AXL inhibitors in cancer: A medicinal chemistry perspective.
    Myers et al.
    J.Med.Chem., 2016;59:3593
  2. Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma.
    Faria et al.
    Cancer Res., 2015;75:134
  3. Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases.
    Qian et al.
    Cancer Res., 2009;69:8009
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