GSK 923295A
Chemical Name: 3-Chloro-N-[(1S)-2-[[2-(dimethylamino)acetyl]amino]-1-[[4-[8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl]phenyl]methyl]ethyl]-4-(1-methylethoxy)benzamide
Purity: ≥97%
Biological Activity
GSK 923295A is a potent and selective centromere associated protein E (CENP-E) allosteric inhibitor (IC50 = 22 nM); does not compete with ATP. Exhibits selectivity over a panel of other kinesins (<25% inhibition at 50 μM). Inhibits tumor cell growth in vitro. Induces mitotic arrest and regression of human tumor xenografts in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Background References
-
Antitumor activity of an allosteric inhibitor of centromere-associated protein-E.
Wood et al.
Proc.Natl.Acad.Sci.U.S.A., 2010;107:5839 -
Discovery of the first potent and selective inhibitor of centromere-associated protein E: GSK923295.
Qian et al.
ACS Med.Chem.Lett., 2010;1:30
Product Datasheets
Reconstitution Calculator
Molarity Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for GSK 923295A
There are currently no reviews for this product. Be the first to review GSK 923295A and earn rewards!
Have you used GSK 923295A?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
