GSK 923295A

Catalog # Availability Size / Price Qty
6837/5
6837/25
GSK 923295A | CAS No. 1088965-37-0 | Kinesin Inhibitors
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Description: Potent and selective centromere associated protein E (CENP-E) allosteric inhibitor

Chemical Name: 3-Chloro-N-[(1S)-2-[[2-(dimethylamino)acetyl]amino]-1-[[4-[8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl]phenyl]methyl]ethyl]-4-(1-methylethoxy)benzamide

Purity: ≥97%

Product Details
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Biological Activity

Potent and selective centromere associated protein E (CENP-E) allosteric inhibitor (IC50 = 22 nM); does not compete with ATP. Exhibits selectivity over a panel of other kinesins (<25% inhibition at 50 μM). Inhibits tumor cell growth in vitro. Induces mitotic arrest and regression of human tumor xenografts in vivo.

Technical Data

M.Wt:
592.13
Formula:
C32H38ClN5O4
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol with gentle warming
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
1088965-37-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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