Catalog Number: 0234
Chemical Name: 1,2,5,6-Tetrahydropyridine-3-carboxylic acid hydrochloride
Biological Activity
Specific GABA uptake inhibitor. IC50 values are 14, 58, 119 and 1870 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively.
Technical Data
  • M.Wt:
    163.6
  • Formula:
    C6H9NO2.HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    6027-91-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Tiagabine, SK&F 89976-A, CI 966, and NNC-711 are selective for the cloned GABA transporter GAT-1.
    Borden et al.
    Eur.J.Pharmacol., 1994;269:219
  2. Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds.
    Krogsgaard-Larsen et al.
    J.Neurochem., 1978;30:1377
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Guvacine hydrochloride include:

1 Citations: Showing 1 - 1

  1. Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2).
    Authors: Edwards Et al.
    Biochim Biophys Acta 2011;1808:260

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