Catalog Number: 4669
Chemical Name: N-[1-(2-Phenylethyl)-1H-benzimidazol-2-yl]benzamide methanesulfonate
Biological Activity
Neuropeptide (NPY) Y5 receptor antagonist (IC50 = 210 nM). Reduces NPY-induced food intake in rodents and decreases weight gain in obese rats.
Technical Data
  • M.Wt:
    437.51
  • Formula:
    C22H19N3O.CH3SO3H
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    469861-49-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline.
Background References
  1. Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist.
    Daniels et al.
    Regul.Pept., 2002;106:47
  2. Neuropeptide Y Y5 receptors inhibit kindling acquisition in rats.
    Benmaamar et al.
    Regul.Pept., 2005;125:79

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