Neuropeptide (NPY) Y5
receptor antagonist (IC50
= 210 nM). Reduces NPY-induced food intake in rodents and decreases weight gain in obese rats.
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Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist.
Daniels et al.
Neuropeptide Y Y5 receptors inhibit kindling acquisition in rats.
Benmaamar et al.