H 89 dihydrochloride

Tocris Bioscience | Catalog # 2910

Protein kinase A inhibitor
Tocris Bioscience

Key Product Details

Description

Protein kinase A inhibitor
View all Protein Kinase A Inhibitors »

Product Description

H 89 dihydrochloride is a protein kinase A inhibitor that also inhibits several other kinases (IC50 values are 80, 120, 135, 270, 2600 and 2800 nM for S6K1, MSK1, PKA, ROCKII, PKBα and MAPKAP-K1b). Exhibits antinociceptive activity. Enhances survival and clonogenicity of dissociated human ESCs through ROCK inhibition.

Product Specifications for H 89 dihydrochloride

Molecular Weight

519.28

Formula

C20H20BrN3O2S.2HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamide dihydrochloride

CAS Number

130964-39-5

PubChem ID

5702541

InChI Key

GELOGQJVGPIKAM-WTVBWJGASA-N

SMILES

O=S(C2=CC=CC1=CN=CC=C12)(NCCNC/C=C/C3=CC=C(Br)C=C3)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 12.98 25
DMSO 51.93 100

Preparing Stock Solutions for H 89 dihydrochloride

The following data is based on the product molecular weight 519.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.93 mL 9.63 mL 19.26 mL
5 mM 0.39 mL 1.93 mL 3.85 mL
10 mM 0.19 mL 0.96 mL 1.93 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 110 publications citing the usage of this product.

Product Documents for H 89 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for H 89 dihydrochloride

For research use only

Citations for H 89 dihydrochloride

Customer Reviews for H 89 dihydrochloride (1)

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  • Product performed ideally over years and would buy again.
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Sprague-Dawley rats primary neuronal
    Verified Customer | Posted 04/04/2020
    10 μM H-89 for 30 min
    H 89 dihydrochloride 2910

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