Protein kinase A inhibitor that also inhibits several other kinases (IC50
values are 80, 120, 135, 270, 2600 and 2800 nM for S6K1, MSK1, PKA, ROCKII, PKBα
and MAPKAP-K1b). Exhibits antinociceptive activity. Also available as part of the PKA TocrisetTM
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The many faces of H89: a review.
Lochner and Moolman
Cardiovasc.Drug Rev., 2006;24:261
Involvement of cAMP response element-binding protein activation in salivary secretion.
Yamada et al.
Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling.
Vitolo et al.
Biphasic modulation of nociceptive processing by the cyclic AMP-protein kinase A signalling pathway in sheep spinal cord.
Dolan and Nolan
The citations listed below are publications that use Tocris products. Selected citations for H 89 dihydrochloride include:
Showing Results 1 - 10 of 22