H 89 dihydrochloride

  ( 29 citations )    
Product Datasheet
Catalog Number:2910
Chemical Name:N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamide dihydrochloride
Product Details
Citations (29)
Reviews
Biological Activity
Protein kinase A inhibitor that also inhibits several other kinases (IC50 values are 80, 120, 135, 270, 2600 and 2800 nM for S6K1, MSK1, PKA, ROCKII, PKBα and MAPKAP-K1b). Exhibits antinociceptive activity. Also available as part of the PKA TocrisetTM.
Technical Data
  • M.Wt:
    519.28
  • Formula:
    C20H20BrN3O2S.2HCl
  • Solubility:
    Soluble to 25 mM in water and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    130964-39-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for H 89 dihydrochloride include:

29 Citations: Showing 1 - 10
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  1. Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers.
    Authors: Nilsson
    Sci Transl Med  2017;9(415):eaao4307
  2. Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson�s disease.
    Authors: Tozzi Et al.
    Cell Death Dis  2017;9(2):204
  3. TDAG8 involved in initiating inflammatory hyperalgesia and establishing hyperalgesic priming in mice.
    Authors: Dai
    Sci Rep  2017;7:41415
  4. β2-adrenoreceptor Inverse Agonist Down-regulates Muscarine Cholinergic Subtype-3 Receptor and Its Downstream Signal Pathways in Airway Smooth Muscle Cells in vitro.
    Authors: Luo
    Scientific Reports  2017;7:39905
  5. Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain.
    Authors: Acuña Et al.
    J Clin Invest  2016;126:2547
  6. Dopamine D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells.
    Authors: Xing Et al.
    Br J Pharmacol  2015;9:310
  7. Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin.
    Authors: Chang Et al.
    Sci Rep  2015;5:10256
  8. Retroactive modulation of spike timing-dependent plasticity by dopamine.
    Authors: Brzosko Et al.
    Elife  2015;4
  9. Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
    Authors: Zhu Et al.
    Cell  2015;35:621
  10. Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells.
    Authors: Parnell Et al.
    Mol Med Rep  2015;1853:1749
  11. A long-acting β2-adrenergic agonist increases the expression of muscarine cholinergic subtype-3 receptors by activating the β2-adrenoceptor cyclic adenosine monophosphate signaling pathway in airway smooth muscle cells.
    Authors: Liu Et al.
    Proc Natl Acad Sci U S A  2015;11:4121
  12. Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38.
    Authors: Toda and Huganir
    J Neurosci  2015;112:6712
  13. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol.
    Authors: Merino Et al.
    PLoS One  2015;10:e0132884
  14. Dopamine Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation.
    Authors: Rioult-Pedotti Et al.
    Cell Death Dis  2015;10:e0124986
  15. Prostaglandin E2 promotes features of replicative senescence in chronically activated human CD8+ T cells.
    Authors: Chou Et al.
    PLoS One  2014;9:e99432
  16. GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization.
    Authors: Adelfinger Et al.
    Biochem Pharmacol  2014;91:369
  17. Separate cyclic AMP sensors for neuritogenesis, growth arrest, and survival of neuroendocrine cells.
    Authors: Emery Et al.
    J Biol Chem  2014;289:10126
  18. δ-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes.
    Authors: Liang Et al.
    Biochim Biophys Acta  2014;171:5417
  19. Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons.
    Authors: Isensee Et al.
    J Cell Sci  2014;127:216
  20. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    PLoS One  2013;8:e66404
  21. PDE3 and PDE4 isozyme-selective inhibitors are both required for synergistic activation of brown adipose tissue.
    Authors: Kraynik Et al.
    PLoS One  2013;83:1155
  22. Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate.
    Authors: Santos-Carvalho Et al.
    Purinergic Signal  2013;4:e636
  23. A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.
    Authors: Jahchan Et al.
    Cancer Discov  2013;3:1364
  24. Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons.
    Authors: Sohn Et al.
    Mol Pharmacol  2013;152:612
  25. The expression and relaxant effect of bitter taste receptors in human bronchi.
    Authors: Grassin-Delyle Et al.
    Respir Res  2013;14:134
  26. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    Nature  2012;492:123
  27. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem  2011;116:984
  28. Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors.
    Authors: Higley and Sabatini
    Nat Neurosci  2010;13:958
  29. IGF-I inhibition of apoptosis is associated with decreased expression of prostate apoptosis response-4.
    Authors: Chung Et al.
    J Endocrinol  2007;194:77
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