Hemokinin 1 (mouse)
Biological ActivityNovel mammalian endogenous peptide, homolog of substance P, that is a high affinity and selective agonist at the tachykinin NK1 receptor (Ki values are 0.175 and 560 nM for NK1 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B-cells in vitro and is antihypertensive in vivo.
(Modifications: Met-11 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological profile of the novel mammalian tachykinin hemokinin 1.
Bellucci et al.
Hemokinin 1 is a full agonist at the substance P receptor.
Morteau et al.
Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis.
Zhang et al.
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