Catalog Number: 1535
Alternate Names: HK-1, HEK-1
Biological Activity
Novel mammalian endogenous peptide, homolog of substance P, that is a high affinity and selective agonist at the tachykinin NK1 receptor (Ki values are 0.175 and 560 nM for NK1 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B-cells in vitro and is antihypertensive in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Met-11 = C-terminal amide)

  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacological profile of the novel mammalian tachykinin hemokinin 1.
    Bellucci et al.
    Br.J.Pharmacol., 2002;135:266
  2. Hemokinin 1 is a full agonist at the substance P receptor.
    Morteau et al.
    Nat.Immunol., 2001;2:1088
  3. Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis.
    Zhang et al.
    Nat.Immunol., 2000;1:392
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