Hemokinin 1 (mouse)

Catalog # Availability Size / Price Qty
1535/1
Hemokinin 1 (mouse)
1 Image
Description: Endogenous, high affinity and selective NK1 agonist
Alternative Names: HK-1, HEK-1
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Biological Activity

Novel mammalian endogenous peptide, homolog of substance P, that is a high affinity and selective agonist at the tachykinin NK1 receptor (Ki values are 0.175 and 560 nM for NK1 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B-cells in vitro and is antihypertensive in vivo.

Technical Data

M.Wt:
1413.66
Formula:
C61H100N22O15S
Sequence:
RSRTRQFYGLM

(Modifications: Met-11 = C-terminal amide)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
208041-90-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Pharmacological profile of the novel mammalian tachykinin hemokinin 1.
    Bellucci et al.
    Br.J.Pharmacol., 2002;135:266
  2. Hemokinin 1 is a full agonist at the substance P receptor.
    Morteau et al.
    Nat.Immunol., 2001;2:1088
  3. Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis.
    Zhang et al.
    Nat.Immunol., 2000;1:392

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