Humanin analog; increases glucose stimulated insulin secretion and glucose metabolism in vivo
and in vitro
. Also enhances glucose sensing in β
TC3 cells and lowers blood glucose in Zucker diabetic fatty rats. Prevents endothelial dysfunction and delays progression of atherosclerosis in vivo
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Humanin Preserves Endothelial Function and Prevents Atherosclerotic Plaque Progression in Hypercholesterolemic ApoE Deficient Mice.
Oh YK, Bachar AR, Zacharias DG et al.
Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell.
Kuliawat et al.
FASEB J., 2013;27:4890
Humanin: a novel central regulator of peripheral insulin action.
Muzumdar et al.
PLoS One., 2009;4:e6334