Catalog Number: 5154
Biological Activity
Humanin analog; increases glucose stimulated insulin secretion and glucose metabolism in vivo and in vitro. Also enhances glucose sensing in βTC3 cells and lowers blood glucose in Zucker diabetic fatty rats. Prevents endothelial dysfunction and delays progression of atherosclerosis in vivo.
Technical Data
  • M.Wt:
    2581.13
  • Formula:
    C112H198N34O31S2
  • Sequence:
    MAPRGASCLLLLTGEIDLPVKRRA
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    1093111-54-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Humanin Preserves Endothelial Function and Prevents Atherosclerotic Plaque Progression in Hypercholesterolemic ApoE Deficient Mice.
    Oh YK, Bachar AR, Zacharias DG et al.
    Atherosclerosis;219(1):65-73.
  2. Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell.
    Kuliawat et al.
    FASEB J., 2013;27:4890
  3. Humanin: a novel central regulator of peripheral insulin action.
    Muzumdar et al.
    PLoS One., 2009;4:e6334

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