hh HU 210 (CAS 112830-95-2): R&D Systems
Catalog Number: 0966
Chemical Name: (6aR)-trans-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methanol
Biological Activity
A highly potent cannabinoid receptor agonist (Ki values are 0.061 and 0.52 nM at cloned human CB1 and CB2 receptors respectively). Induces spatial memory deficits and suppresses hippocampal firing rates in rats. Also displays agonist activity at GPR55 (EC50 = 26 nM).
Technical Data
  • M.Wt:
    386.57
  • Formula:
    C25H38O3
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    112830-95-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Citations:

The citations listed below are publications that use Tocris products. Selected citations for HU 210 include:

16 Citations: Showing 1 - 10
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  1. Cannabinoid HU210 protects isolated rat stomach against impairment caused by serum of rats with experimental acute pancreatitis.
    Authors: Cao Et al.
    PLoS One 2013;7:e52921
  2. Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism.
    Authors: Lim Et al.
    Br J Pharmacol 2013;365:303
  3. Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity.
    Authors: Butti Et al.
    Brain 2012;135:3320
  4. CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3β/β-catenin signaling.
    Authors: Trazzi Et al.
    Br J Pharmacol 2010;285:10098
  5. Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells.
    Authors: Rajesh Et al.
    Br J Pharmacol 2010;160:688
  6. Cannabinoid receptor activation reverses kainate-induced synchronized population burst firing in rat hippocampus.
    Authors: Mason and Cheer
    Front Integr Neurosci 2009;3:13
  7. Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity.
    Authors: Mukhopadhyay Et al.
    J Am Coll Cardiol 2007;50:528
  8. Cannabinoid action in the olfactory epithelium.
    Authors: Czesnik Et al.
    Proc Natl Acad Sci U S A 2007;104:2967
  9. Induction of Krox-24 by endogenous cannabinoid type 1 receptors in Neuro2A cells is mediated by the MEK-ERK MAPK pathway and is suppressed by the phosphatidylinositol 3-kinase pathway.
    Authors: Graham Et al.
    J Biol Chem 2006;281:29085
  10. Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models.
    Authors: Jayamanne Et al.
    J Biol Chem 2006;147:281
  11. Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor.
    Authors: Savinainen Et al.
    Br J Pharmacol 2005;145:636
  12. An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors.
    Authors: Savinainen Et al.
    Br J Pharmacol 2003;140:1451
  13. Gastric antisecretory role and immunohistochemical localization of cannabinoid receptors in the rat stomach.
    Authors: Adami Et al.
    Br J Pharmacol 2002;135:1598
  14. Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human.
    Authors: Martin Et al.
    Br J Pharmacol 2000;129:1707
  15. Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice.
    Authors: Zimmer Et al.
    J Biol Chem 1999;96:5780
  16. Cannabinoid CB1 receptor and endothelium-dependent hyperpolarization in guinea-pig carotid, rat mesenteric and porcine coronary arteries.
    Authors: Chataigneau Et al.
    Proc Natl Acad Sci U S A 1998;123:968
Expand to show all 16 Citations

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