Human Apolipoprotein E/ApoE Alexa Fluor® 488-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Apolipoprotein E3/ApoE3

ApoE is a 34 kDa protein component of serum chylomicrons, VLDL, and HDL particles. It mediates the binding, uptake, and catabolism of these particles through interactions with the ApoE receptor and LDL receptors in the liver and brain. ApoE is important in fatty acid homeostasis and memory formation. Polymorphisms encode three variants (ApoE2, 3, 4) which are differentially related to the development of atherosclerosis and neurogenerative disorders. Mature human ApoE shares 71% amino acid sequence identity with mouse and rat ApoE.

Product Datasheets

Related Research Areas

• Glucose Homeostasis
• Lipid and Fatty Acid Transport
• Lipid/Cholesterol Metabolism
• Obesity
• Transport of Amyloid beta Across the Blood-Brain Barrier