B7-2/CD86 and the related B7-1/CD80 are transmembrane cell surface molecules that play important roles in immune activation and the maintenance of immune tolerance. B7-2 is highly expressed on activated antigen presenting cells and vascular endothelial cells. It binds to CD28 on T cells to enhance T cell activation. It additionally binds CTLA-4 which inhibits the T cell response and supports regulatory T cell function. The relative participation of B7-1 and B7-2 in T cell co-stimulation can alter the Th1/Th2 bias of the immune response. Both B7-1 and B7-2 serve as cellular receptors for B species adenoviruses.
Human B7-2/CD86 (NP_787058) VersaClone cDNA
R&D Systems | Catalog # RDC0693
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: B7-2/CD86
Alternate Names
B72, CD86
Gene Symbol
CD86
UniProt
Additional B7-2/CD86 Products
Product Documents for Human B7-2/CD86 (NP_787058) VersaClone cDNA
Certificate of Analysis
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Note: Certificate of Analysis not available for kit components.
Product Specific Notices for Human B7-2/CD86 (NP_787058) VersaClone cDNA
For research use only
Citations for Human B7-2/CD86 (NP_787058) VersaClone cDNA
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