Human Bax aa 3-16 Antibody

Discontinued Product

2282-MC has been discontinued.
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Product Details
Citations (8)
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Human Bax aa 3-16 Antibody Summary

Species Reactivity
Human
Specificity
Anti-Bax (Clone YTH-2D2) cross reacts with human Bax.
Source
Monoclonal Mouse IgG1 Clone # YTH-2D2
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Human Bax
aa 3-16
Formulation
This antibody is provided as purified immunoglobulin from mouse ascites in 1X PBS containing 0.01% sodium azide.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1:1000 dilution
Immunoprecipitation
Please refer to the PDF datasheet for specifications.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4 °C.

Background: Bax

The Bcl-2 family of proteins plays a crucial role in the regulation of cell death in many eukaryotic systems. Bax has been shown to redistribute from the cytosol to the mitochondria during apoptosis, and overexpression of Bax can accelerate cell death. Coregulation of Bax dimer formation and intracellular localization are associated with Bax conformational changes. Anti-Bax YTH-2D2 is specific for human Bax and does not crossreact with mouse or rat Bax. When used in conjunction with the anti-Bax YTH-6A7 (Catalog # 2281-MC), which recognizes only detergent treated Bax, the researcher may selectively identify the activated form of Bax.

References
  1. Suzuki, M. et al. 2000, Cell 103:645-54.
  2. Hsu, Y.-T. et al. 1997, Proc. Natl. Acad. Sci. USA 94:3668-3672.
  3. Hsu, Y.-T. and R.J. Youle. 1997, J. Biol. Chem. 272:13829-13834.
  4. Neuchushtan, A. et al. 1999, EMBO J. 18:2330-2341.
Long Name
Bcl Associated X Protein
Entrez Gene IDs
581 (Human); 12028 (Mouse); 24887 (Rat)
Alternate Names
apoptosis regulator BAX; Bax; BCL2-associated X protein; Bcl2-L-4; BCL2L4bcl2-L-4; Bcl-2-like protein 4

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Citations for Human Bax aa 3-16 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

8 Citations: Showing 1 - 8
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  1. TRAF3/p38-JNK Signalling Crosstalk with Intracellular-TRAIL/Caspase-10-Induced Apoptosis Accelerates ROS-Driven Cancer Cell-Specific Death by CD40
    Authors: K Ibraheem, AMA Yhmed, MM Nasef, NT Georgopoul
    Cells, 2022;11(20):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  2. A redox state-dictated signalling pathway deciphers the malignant cell specificity of CD40-mediated apoptosis
    Oncogene, 2016;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  3. Dietary flavonoids inhibit the anticancer effects of the proteasome inhibitor bortezomib.
    Authors: Liu FT, Agrawal SG, Movasaghi Z, Wyatt PB, Rehman IU, Gribben JG, Newland AC, Jia L
    Blood, 2008;112(9):3835-46.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  4. Increased proteasomal degradation of Bax is a common feature of poor prognosis chronic lymphocytic leukemia.
    Authors: Agrawal SG, Liu FT, Wiseman C, Shirali S, Liu H, Lillington D, Du MQ, Syndercombe-Court D, Newland AC, Gribben JG, Jia L
    Blood, 2007;111(5):2790-6.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  5. HA14-1, a small molecule inhibitor of Bcl-2, bypasses chemoresistance in leukaemia cells.
    Authors: Oliver L, Mahe B, Gréé R, Vallette FM, Juin P
    Leuk. Res., 2007;31(6):859-63.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  6. Bcl-2 inhibitors sensitize tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by uncoupling of mitochondrial respiration in human leukemic CEM cells.
    Authors: Hao JH, Yu M, Liu FT, Newland AC, Jia L
    Cancer Res., 2004;64(10):3607-16.
    Species: Human
    Sample Types: Whole Cells
    Applications: Western Blot
  7. Increase in the ratio of mitochondrial Bax/Bcl-XL induces Bax activation in human leukemic K562 cell line.
    Authors: Liu FT, Goff LK, Hao JH, Newland AC, Jia L
    Apoptosis, 2004;9(3):377-84.
    Species: Human
    Sample Types: Mitochondria
    Applications: Immunoprecipitation
  8. Bax translocation is crucial for the sensitivity of leukaemic cells to etoposide-induced apoptosis.
    Authors: Jia L, («e͍֗R, Patwari Y, Srinivasula SM, Newland AC, Fernandes-Alnemri T, Alnemri ES, Kelsey SM
    ÔÏŒ?RoPJZ¤ ÁÅù$âзšÇ®å:AgÁž´²¾»<³“ÕEN½;ò°rÓ¦Ò°ލ/fø_kŠ¾ûÎnîålŸT¯¤:Qº3I`¨Ò, 2001;20(35):4817-26.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot

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