Human BIK Alexa Fluor® 750-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: BIK

Bcl-2-interacting killer (BIK; also known as NBK, BP4 and BIP-1) is a 19 kDa member of the BH3-only subfamily, Bcl-2 family of proteins. It is widely expressed, and serves as an initiator of cell death. It apparently participates in apoptosis by sequestering antiapoptotic cytoplasmic proteins of the Bcl-2 family and in autophagy by regulating cytosolic calcium levels. Human BIK-1 is 160 amino acids (aa) in length. It contains one BH3 domain (aa 57‑74), a “death segment” (aa 121‑134) and a transmembrane domain (aa 136‑156). BIK is likely to embed in both outer mitochondrial and ER membranes. Over amino acids 1‑135, human BIK shares only 45% aa identity with mouse BIK.

Product Datasheets

Related Research Areas

• Bcl-2 Proteins and Regulators