Human BRCA1 C-Terminus Alexa Fluor® 750-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: BRCA1

The BRCA1 (BReast CAncer gene 1) tumor suppressor protein has many reported functions. In addition to mediating signal transduction in DNA damage and repair responses, BRCA1 forms a heterodimer with BARD1 and regulates transcriptional activity, assisting in the preservation of chromosomal stability. BRCA1 is one of the first proteins recruited to sites of DNA double-strand breaks and serves as part of a scaffold for assembling other DNA damage response or repair factors, including MSH2, MLH1, ATM and PMS2.

Product Datasheets

Related Research Areas

• Cancer Biomarkers
• DNA Damage and Repair
• DNA Repair
• E3 Ubiquitin Ligases
• Nucleotide Excision Repair/Transcription Coupled Repair
• Positive Regulators of the Jak/STAT Pathway
• Ubiquitin-related Molecules in the Akt Pathway