Human CaM Kinase II alpha Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB5584R Datasheet / COA / SDS

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FAB5584R-100UG

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Human CaM Kinase II alpha Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human CaM Kinase II alpha in direct ELISAs.

Source

Monoclonal Mouse IgG2b Clone # 525501

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human CaM Kinase IIÎ±
Ala144-Ala262
Accession # Q9UQM7

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: CaM Kinase II alpha

Calcium/calmodulin-dependent protein kinase type II alpha (CaMKII alpha ) belongs to a family of multifunctional serine/threonine kinases activated in response to increases in intracellular calcium. There are 4 CaMKII isozymes, alpha, beta, gamma, and δ, and each can yield several isoforms through alternative splicing. CaMKII isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. CaMKII alpha is predominantly expressed in the brain. It shares 100% aa sequence identity between human, mouse, and rat within aa 144‑262 of isoform 1.

Long Name

Calcium/Calmodulin-dependent Protein Kinase II alpha

Entrez Gene IDs

815 (Human); 12322 (Mouse); 25400 (Rat)

Alternate Names

calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase II alpha-B subunit; CaM kinase II alpha subunit; CaM Kinase II alpha; CaM kinase II subunit alpha; CAMK2A; CAMKAcalcium/calmodulin-dependent protein kinase type II subunit alpha; CaMK-II alpha subunit; CaMK-II subunit alpha; CaMKIINalpha; CaM-kinase II alpha chain; EC 2.7.11; EC 2.7.11.17; KIAA0968calcium/calmodulin-dependent protein kinase type II alpha chain