Human CCL23/MPIF‑1 Biotinylated Antibody

Catalog # Availability Size / Price Qty
Product Details
Citations (1)
Supplemental Products

Human CCL23/MPIF‑1 Biotinylated Antibody Summary

Species Reactivity
Detects human CCL23/MPIF-1 in ELISAs and Western blots. In sandwich immunoassays, approximately 10% cross-reactivity with recombinant human (rh) CK beta 8-1 (a splice variant of rhMPIF-1) is observed, and less than 0.1% cross-reactivity with rhHCC-1, rhMIP-1δ, and rhMPIF-2 is observed.
Polyclonal Goat IgG
Antigen Affinity-purified
E. coli-derived recombinant human CCL23/MPIF-1 (R&D Systems, Catalog # 371-MP)
Accession # P55773
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Human CCL23/MPIF‑1 (Catalog # 371-MP)

Human CCL23/MPIF-1 Sandwich Immunoassay

Recommended Concentration
ELISA Detection (Matched Antibody Pair)
0.1-0.4 µg/mL 

Use in combination with:

Capture Reagent: Human CCL23/MPIF‑1 Antibody (Catalog # MAB3711)

Standard: Recombinant Human CCL23/MPIF-1 Protein (Catalog # 371-MP)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CCL23/MPIF-1

Myeloid progenitor inhibitory factor (MPIF-1), also known as CK beta 8 and MIP-3, is a member of the CC chemokine subfamily that is designated CCL23. Alternative splicing of the MPIF-1 gene results in two mRNAs that encode a short (CK beta 8) and a long (CK beta 8-1) isoform of the chemokine. CK beta 8 cDNA encodes a 120 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide that is cleaved to generate a 99 aa residue mature CK beta 8 (aa 22 - 120). Additional N-terminal processing of the 99 aa residue variant can generate a 75 aa residue CK beta 8 (aa 46 - 120) that is significantly more active than the 99 aa residue variant. Similarly, CK beta 8-1 encodes a 137 aa residue precursor protein that can give rise to a 116 and a 92 aa residue chemokine. Among CC chemokine members, MPIF-1 is most closely related to MIP-5/CCL15 (67% sequence identity) and MIP-1 alpha /CCL3 (51%). MPIF-1 mRNA is most abundant in the adult lung and liver, but is also present in bone marrow, placenta, and various myelomonocytic cell lines. MPIF-1 has been shown to suppress the low proliferative potential colony-forming cells that give rise to granulocyte and monocyte lineages. MPIF-1 binds to CCR1 with high affinity and has been shown to be a potent chemoattractant and activator of monocytes, dendritic cells, and osteoclast precursors.

  1. Patel, V. et al. (1997) J. Exp. Med. 185:1163.
  2. Youn, B-S. et al. (1998) Blood 91:3118.
  3. Nardelli, B. et al. (1999) J. Leukoc. Biol. 61:822.
  4. Berkhout, T.A. et al. (2000) Biochem. Pharmacol. 59:591.
Entrez Gene IDs
6368 (Human)
Alternate Names
CCL23; CCL23/MPIF-1; CCL23;CKb8;Ckb-8;Ckb-8-1;CK-BETA-8;hmrp-2a;MIP3;MIP-3;MPIF1;MPIF-1;SCYA23; MPIF1; MPIF-1

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Citation for Human CCL23/MPIF‑1 Biotinylated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. CCL23 expression is induced by IL-4 in a STAT6-dependent fashion.
    Authors: Novak H, Muller A, Harrer N, Gunther C, Carballido JM, Woisetschlager M
    J. Immunol., 2007;178(7):4335-41.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development


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