Detection of CCR11 in NS0 Mouse Cell Line Transfected with Human CCR11 and eGFP by Flow Cytometry. NS0 mouse myeloma cell line transfected with human CCR11 and eGFP was stained with Mouse Anti-Human CCR11 APC‑conjugated Monoclonal Antibody (Catalog # FAB6899A). Quadrant markers were set based on control antibody staining (Catalog # IC015A). View our protocol for Staining Membrane-associated Proteins.
Detection of CCR11 in MCF‑7 Human Cell Line by Flow Cytometry. MCF‑7 human breast cancer cell line was stained with Mouse Anti-Human CCR11 APC‑conjugated Monoclonal Antibody (Catalog # FAB6899A, filled histogram) or isotype control antibody (Catalog # IC015A, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
12 months from date of receipt, 2 to 8 °C as supplied.
CCR11, also known as CCRL1 and CCX-CKR, is a 45 kDa 7-transmembrane segment protein that is widely expressed on stromal cells. It is a silent receptor that does not induce intracellular calcium signaling, but instead serves as a chemokine scavenger receptor. CCR11 regulates dendritic cell and thymic precursor migration by mediating the clearance of the homeostatic chemokines CCL19, 21, and 25. It is upregulated on some breast cancer cells and on bronchial epithelial cells in pulmonary sarcoidosis. Human CCR11 shares 85% amino acid sequence identity with mouse and rat CCR11.
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