Human CD19 (NP_001761) VersaClone cDNA Summary
CD19 is a 95 kDa transmembrane glycoprotein with two Ig-like C2-set domains. CD19 regulates B cell development and activation through interactions with CD21, CD22, and the B cell receptor. CD19 polymorphisms and upregulation lead to the development of autoimmunity by promoting autoantibody production. Its downregulation is associated with the malignant phenotype in multiple myeloma.
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