Human Chondroadherin Alexa Fluor® 350-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Chondroadherin

Chondroadherin is an approximately 36 kDa secreted glycosaminoglycan that contains nine tandem leucine-rich repeats as well as N-terminal and C-terminal leucine-rich domains. It is a component of the extracellular matrix in cartilage, tendon, bony growth plates, skeletal and cardiac muscle, lung, gastrointestinal tract, pancreas, cerebellum, and eye. It is cleaved by HTRA1/Omi during intervertebral disc degeneration. Chondroadherin functions as an adhesion protein by binding to Integrin a2/b1, Collagen II, and Collagen VI. It also promotes complement activation through binding to C1q and Complement Factor H. Mature human Chondroadherin shares 94% amino acid sequence identity with mouse and rat Chondroadherin.

Product Datasheets

Related Research Areas

• Adhesion Molecules in Angiogenesis
• Chondrogenesis Markers
• Integrins and Associated Molecules
• Proteoglycans