Human COUP-TF II/NR2F2 Antibody
Summary
Preparation and Storage
Reconstitution Calculator
Background
Product Datasheets
Related Research Areas
Human COUP-TF II/NR2F2 Antibody Summary
Species Reactivity
Human
Specificity
This antibody specifically recognizes human COUP-TF II and cross-reacts with rat COUP-TF II. This antibody does not cross-react with human COUP-TF I or EAR2. Not yet tested in other species.
Source
Monoclonal Mouse IgG2A Clone # H7147
Purification
Protein A or G purified from ascites
Immunogen
Recombinant human COUP-TF II/NR2F2
Amino Acids 43-64
Amino Acids 43-64
Formulation
A liquid formulation in physiologic saline with 0.1% NaN3.
Label
Unconjugated
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Applications
Recommended Concentration
Sample
Western Blot
This antibody can be used at 1 μg/mL with the appropriate secondary reagents to detect human COUP-TF II.
Immunohistochemistry
This antibody can be used at 10 ug/mL with the appropriate secondary reagents to detect human COUP-TF II alpha.
Immunoprecipitation
Optimal dilutions should be determined by each laboratory.
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Reconstitution Calculator
Preparation and Storage
Shipping
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
This antibody is stable for greater than six months when held at -20° C in a manual defrost freezer or at -70° C. Upon thawing, the antibody can be stored at 2° - 8° C for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Background: COUP-TF II/NR2F2
Chicken ovalbumin upstream promoter transcription factor II (COUP-TF II, ARP-1, COUP-TFB; NR2F2) is a member of the orphan nuclear receptorfamily. COUP-TF II is expressed in the tongue, follicles of vibrissae, cochIea and in stroma of the nasal septum. COUP-TF II has roles in angiogenesis, vascular remodeling and heart development. COUP-TFs were shown to interact with a number of other nuclear receptors.
Long Name
COUP Transcription Factor 1/Nuclear Receptor Subfamily 2, Group F, Member 2
Entrez Gene IDs
7026 (Human)
Alternate Names
Apolipoprotein A-I regulatory protein 1; ARP-1; ARP1ADP-ribosylation factor related protein 1; chicken ovalbumin upstream promoter transcription factor 2; COUP transcription factor 2; COUP transcription factor II; COUPTF II; COUP-TF II; COUP-TF2; COUPTFB; COUPTFII; COUP-TFII; MGC117452; NR2F2; Nuclear receptor subfamily 2 group F member 2; nuclear receptor subfamily 2, group F, member 2; SVP40; TFCOUP2apolipoprotein AI regulatory protein 1
Product Datasheets
Citations for Human COUP-TF II/NR2F2 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
26
Citations: Showing 1 - 10
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Somatic cell fate maintenance in mouse fetal testes via autocrine/paracrine action of AMH and activin B
Authors: KF Rodriguez, PR Brown, CM Amato, B Nicol, CF Liu, X Xu, HH Yao
Nature Communications, 2022;13(1):4130.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Modeling human multi-lineage heart field development with pluripotent stem cells
Authors: D Yang, J Gomez-Garc, S Funakoshi, T Tran, I Fernandes, GD Bader, MA Laflamme, GM Keller
Cell Stem Cell, 2022;29(9):1382-1401.e8.
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BRN2 as a key gene drives the early primate telencephalon development
Authors: X Zhu, Y Guo, C Chu, D Liu, K Duan, Y Yin, C Si, Y Kang, J Yao, X Du, J Li, S Zhao, Z Ai, Q Zhu, W Ji, Y Niu, T Li
Science Advances, 2022;8(9):eabl7263.
Species: Primate (Macaca fascicularis)
Sample Types: Whole Tissue
Applications: IHC -
The embryonic ontogeny of the gonadal somatic cells in mice and monkeys
Authors: K Sasaki, A Oguchi, K Cheng, Y Murakawa, I Okamoto, H Ohta, Y Yabuta, C Iwatani, H Tsuchiya, T Yamamoto, Y Seita, M Saitou
Cell Reports, 2021;35(5):109075.
Species: Cynomolgus Monkey
Sample Types: Whole Tissue
Applications: IHC -
Immature excitatory neurons develop during adolescence in the human amygdala
Authors: SF Sorrells, MF Paredes, D Velmeshev, V Herranz-Pé, K Sandoval, S Mayer, EF Chang, R Insausti, AR Kriegstein, JL Rubenstein, J Manuel Gar, EJ Huang, A Alvarez-Bu
Nat Commun, 2019;10(1):2748.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Retinoic Acid Regulates Endothelial ?-catenin Expression and Pericyte Numbers in the Developing Brain Vasculature
Authors: S Bonney, BJC Dennison, M Wendlandt, JA Siegenthal
Front Cell Neurosci, 2018;12(0):476.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI
Authors: M Absinta, SK Ha, G Nair, P Sati, NJ Luciano, M Palisoc, A Louveau, KA Zaghloul, S Pittaluga, J Kipnis, DS Reich
Elife, 2017;6(0):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Abnormal arterial-venous fusions and fate specification in mouse embryos lacking blood flow
Authors: JJ Hwa, N Beckouche, L Huang, Y Kram, H Lindskog, RA Wang
Sci Rep, 2017;7(1):11965.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations
Authors: JH Lee, SI Protze, Z Laksman, PH Backx, GM Keller
Cell Stem Cell, 2017;21(2):179-194.e4.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
The transcription factor Foxg1 promotes optic fissure closure in the mouse by suppressing Wnt8b in the nasal optic stalk
Authors: R Smith, YT Huang, T Tian, D Vojtasova, O Mesalles-N, SM Pollard, T Pratt, DJ Price, V Fotaki
J. Neurosci., 2017;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer
Authors: SC Lin, CY Kao, HJ Lee, CJ Creighton, MM Ittmann, SJ Tsai, SY Tsai, MJ Tsai
Nat Commun, 2016;7(0):11418.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Diverse Functions of Retinoic Acid in Brain Vascular Development
J Neurosci, 2016;36(29):7786-801.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Distinct cortical and sub-cortical neurogenic domains for GABAergic interneuron precursor transcription factors NKX2.1, OLIG2 and COUP-TFII in early fetal human telencephalon
Authors: Ayman Alzu'bi
Brain Struct Funct, 2016;0(0):.
Species: Human
Sample Types: Whole Tissue
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COUP-TFII regulates satellite cell function and muscular dystrophy
J Clin Invest, 2016;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: ChIP -
COUP-TFII inhibits NFkappaB activation in endocrine-resistant breast cancer cells.
Authors: Litchfield L, Appana S, Datta S, Klinge C
Mol Cell Endocrinol, 2014;382(1):358-67.
Species: Human
Sample Types: Cell Lysates
Applications: Immunoprecipitation -
Molecular identification of venous progenitors in the dorsal aorta reveals an aortic origin for the cardinal vein in mammals.
Authors: Lindskog, Henrik, Kim, Yung Hae, Jelin, Eric B, Kong, Yupeng, Guevara-Gallardo, Salvador, Kim, Tyson N, Wang, Rong A
Development, 2014;141(5):1120-8.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Instruction of circulating endothelial progenitors in vitro towards specialized blood-brain barrier and arterial phenotypes.
Authors: Boyer-Di Ponio J, El-Ayoubi F, Glacial F, Ganeshamoorthy K, Driancourt C, Godet M, Perriere N, Guillevic O, Couraud P, Uzan G
PLoS ONE, 2014;9(1):e84179.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC -
Gremlin 2 promotes differentiation of embryonic stem cells to atrial fate by activation of the JNK signaling pathway.
Authors: Tanwar V, Bylund J, Hu J, Yan J, Walthall J, Mukherjee A, Heaton W, Wang W, Potet F, Rai M, Kupershmidt S, Knapik E, Hatzopoulos A
Stem Cells, 2014;32(7):1774-88.
Species: Mouse
Sample Types: Whole Cells
Applications: IHC -
Proposed role for COUP-TFII in regulating fetal Leydig cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents.
Authors: van den Driesche S, Walker M, McKinnell C, Scott HM, Eddie SL, Mitchell RT, Seckl JR, Drake AJ, Smith LB, Anderson RA, Sharpe RM
PLoS ONE, 2012;7(5):e37064.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Endogenous Purification Reveals GREB1 as a Key Estrogen Receptor Regulatory Factor.
Authors: Mohammed H
Oncogene, 2012;3(2):342-9.
Species: Human
Sample Types: Cell Lysates
Applications: ChIP -
Chicken Ovalbumin Upstream Promoter Transcription Factor II Regulates Renin Gene Expression.
Authors: Mayer S, Roeser M, Lachmann P
J. Biol. Chem., 2012;287(29):24483-91.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast cancer cells.
Authors: Litchfield LM, Riggs KA, Hockenberry AM, Oliver LD, Barnhart KG, Cai J, Pierce WM, Ivanova MM, Bates PJ, Appana SN, Datta S, Kulesza P, McBryan J, Young LS, Klinge CM
PLoS ONE, 2012;7(5):e38278.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
A regulatory circuitry comprised of miR-302 and the transcription factors OCT4 and NR2F2 regulates human embryonic stem cell differentiation.
Authors: Rosa A, Brivanlou AH,
EMBO J., 2011;30(2):237-48.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development.
Authors: Lin FJ, Chen X, Qin J, Hong YK, Tsai MJ, Tsai SY
J. Clin. Invest., 2010;120(5):1694-707.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western Blot -
SCF induces gamma-globin gene expression by regulating downstream transcription factor COUP-TFII.
Authors: Aerbajinai W, Zhu J, Kumkhaek C, Chin K, Rodgers GP
Blood, 2009;114(1):187-94.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
The transcription factor COUP-TFII is negatively regulated by insulin and glucose via Foxo1- and ChREBP-controlled pathways.
Authors: Perilhou A, Tourrel-Cuzin C, Kharroubi I, Henique C, Fauveau V, Kitamura T, Magnan C, Postic C, Prip-Buus C, Vasseur-Cognet M
Mol. Cell. Biol., 2008;28(21):6568-79.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot
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Human COUP-TF II/NR2F2 Antibody
By Anonymous
on 08/17/2021
Application: IHC
Sample Tested: Kidney angiomyolipoma
Species:
Human
