Human CTRP1/C1qTNF1 Alexa Fluor™ Plus 680‑conjugated Antibody

R&D Systems | Catalog # FAB10445AFP680

R&D Systems

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Western Blot

Label

Alexa Fluor Plus 680 (Excitation = 687 nm, Emission = 704 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 395520
View all CTRP1/C1qTNF1 Primary Antibodies »

Product Specifications

Specificity

Detects human CTRP1/C1qTNF1 in direct ELISAs.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Human CTRP1/C1qTNF1 Alexa Fluor™ Plus 680‑conjugated Antibody

Application
Recommended Usage

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: CTRP1/C1qTNF1

C1qTNF1 (CTRP1) is an approximately 35 kDa member of the C1q family of secreted proteins and plays a role in energy metabolism and inflammation (1, 2). C1qTNF1 contains a collagen-like region and one C1q-like domain (3). Mature human C1qTNF1 shares 80% aa sequence identity with mouse and rat C1qTNF1. Circulating levels of C1qTNF1 are elevated in obesity, hypertension, and diabetes but can be decreased in the serum of diet-induced obese mice (4-6). C1qTNF1 expression is up-regulated in atherosclerotic plaques or adipose tissue by oxidized LDL or inflammatory cytokines (3, 7, 8). In turn, it induces the expression of inflammatory cytokines (7, 9) and the up-reglation of adhesion proteins on vascular endothelial cells (8). Systemically administered C1qTNF1, in contrast, can limit tissue damage following myocardial infarction (9). In skeletal muscle, C1qTNF1 promotes fatty acid oxidation, energy expenditure, insulin sensitivity, and glucose uptake and glycolysis (6, 10). It also induces the proliferation of immature chondrocytes (11) and aldosterone synthesis in the adrenal cortex (4). R&D Systems in-house testing indicates that C1qTNF1 binds to BAI3, consistent with the reported interactions between BAI3 and C1qL proteins (12).

References

  1. Grebrehiwet, B. et al. (2012) Front. Immunol. 5:3.
  2. Seldin, M.M. et al. (2014) Rev. Endocr. Metab. Disord. 15:111.
  3. Kim, K.-Y. et al. (2006) FEBS Lett. 580:3953.
  4. Jeon, J.H. et al. (2008) FASEB J. 22:1502.
  5. Xin, Y. et al. (2014) Endocr. J. 61:841.
  6. Peterson, J. M. et al. (2012) J. Biol. Chem. 287:1576.
  7. Wang, X.Q. et al. (2016) Atherosclerosis 250:38.
  8. Lu, L. et al. (2016) Eur. Heart J. 37:1762.
  9. Yuasa, D. et al. (2016) FASEB J. 30:1065.
  10. Han, S. et al. (2016) J. Nutr. Biochem. 27:43.
  11. Akiyama, H. et al. (2013) Mol. Cell. Endocrinol. 369:63.
  12. Bolliger, M.F. et al. (2011) Proc. Natl. Acad. Sci. USA 108:2534.

Long Name

C1q And Tumor Necrosis Factor Related Protein 1

Alternate Names

C1qTNF1, ZSIG37

Entrez Gene IDs

114897 (Human); 56745 (Mouse); 303701 (Rat)

Gene Symbol

C1QTNF1

UniProt

Q9BXJ1

Additional CTRP1/C1qTNF1 Products

Product Documents for Human CTRP1/C1qTNF1 Alexa Fluor™ Plus 680‑conjugated Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human CTRP1/C1qTNF1 Alexa Fluor™ Plus 680‑conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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Protocols

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