Human CXADR Antibody
Human CXADR Antibody Summary
Accession # P78310
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
CXADR (coxsackie and adenovirus receptor), also known as CAR, is a 46 kDa type I transmembrane glycoprotein that belongs to the CTX family of the Ig superfamily (1‑3). CXADR has received attention as a receptor that facilitates gene transfer mediated by most adenoviruses (1, 2). It is also an adhesion molecule within junctional complexes, notably between epithelial cells lining body cavities and within myocardial intercalated discs (1, 2, 4). CXADR is essential for normal cardiac development in the mouse (7). It is expressed throughout brain neuroepithelium during development, but mainly in ependymal cells in the adult (4‑6). The 365 amino acid (aa) human CXADR contains a 19 aa signal sequence, a 218 aa extracellular domain (ECD) with a V-type (D1) and a C2-type (D2) Ig-like domain, a 21 aa transmembrane segment and a 107 aa intracellular domain. D1 is thought to be responsible for homodimer formation in trans within tight junctions (2). The fiber knob of adenoviruses attaches at a similar site, and evidence suggests that disruption of tight junctions facilitates virus binding (1, 2). The C‑terminus interacts with several cytoplasmic junctional proteins, microtubules and the actin cytoskeleton (1, 8, 9). The ECD of human CXADR shares 90% aa sequence identity with mouse, rat, and porcine CXADR, and 92% and 89% aa identity with bovine and canine CXADR, respectively. An alternately spliced isoform (CXADR2) that diverges in the C‑terminal 15 aa shows a similar expression pattern (4, 10). Transcription of splice variants that produce soluble forms of CXADR has been detected, and secreted forms in serum and pleural fluid potentially block viral infection (11).
- Coyne, C.B. and J.M. Bergelson (2005) Adv. Drug Deliv. Rev. 57:869.
- Philipson, L. and R.F. Pettersson (2004) Curr. Top. Microbiol. Immunol. 273:87.
- Tomko, R.P. et al. (1997) Proc. Natl. Acad. Sci. USA 94:3352.
- Raschperger, E. et al. (2006) Exp. Cell Res. 312:1566.
- Hotta, Y. et al. Dev. Brain Res. 143:1.
- Hauwel, M. et al. (2005) Brain Res. Rev. 48:265.
- Chen, J. et al. (2006) Circ. Res. 98:923.
- Fok, P.T. et al. (2007) J. Biol. Chem. 282:7512.
- Huang, K-C. et al. (2007) FEBS Lett. 581:2702.
- Mirza, M. et al. (2006) Exp. Cell Res. 312:817.
- Bernal, R.M. et al. (2002) Clin. Cancer Res. 8:1915.
Citation for Human CXADR Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
Exogenous LRRK2G2019S induces parkinsonian-like pathology in a nonhuman primate
Authors: N Mestre-Fra, N Serratrice, A Gennetier, G Devau, S Cobo, SG Trouche, P Fontès, C Zussy, P De Deurwae, S Salinas, FJ Mennechet, J Dusonchet, BL Schneider, I Saggio, V Kalatzis, MR Luquin-Piu, JM Verdier, EJ Kremer
JCI Insight, 2018;3(14):.
Sample Types: Whole Tissue
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