Human CXCR4 Alexa Fluor® 405-conjugated Antibody Summary
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
CXCR4, also known as CD184, is a G-protein-linked seven transmembrane spanning receptor that binds stromal cell-derived factor-1 (SDF-1). CXCR4 acts as a co-factor for T-cell tropic HIV-1 and -2 viral entry into cells. While primarily a membrane protein, CXCR4 undergoes trafficking and internalization in response to stimulation with phorbol esters and ligand (1). Cytoplasmic and nuclear localization of CXCR4 has been observed in colorectal and renal carcinomas (2,3) and it has been used as the basis of prognosis and metastatic state (3,4,5).
- Orsini, M.J. et al. (1999) J. Biol. Chem. 274:31076.
- Zagzag, D. et al. (2005) Cancer Res. 65:6178.
- Speetjens, F.M. et al. (2009) Cancer Microenvironment 2:1.
- Wang, L. et al. (2009) Oncology Reports 22:1333.
- Amara, S. et al. (2015) Cancer Biomark. 15:869.
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