Human DPPII/QPP/DPP7 Antibody

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Product Details
Supplemental Products

Human DPPII/QPP/DPP7 Antibody Summary

Species Reactivity
Detects human DPPII/QPP/DPP7 in direct ELISAs.
Monoclonal Rat IgG2A Clone # 398011
Protein A or G purified from hybridoma culture supernatant
Mouse myeloma cell line NS0-derived recombinant human DPPII/QPP/DPP7
Accession # ABM85563
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.


Recommended Concentration
Measured by its ability to neutralize Recombinant Human DPPII/QPP/DPP7 (0.1 µg/mL, Catalog # 3438-SE) cleavage of the fluorogenic peptide substrate KP-AMC (10 µM). The Neutralization Dose (ND50) is typically 0.12 µg/mL.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Reconstitute at 0.5 mg/mL in sterile PBS.
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: DPPII/QPP/DPP7

Dipeptidyl-peptidase II (DPPII) is identical to quiescent cell proline dipeptidase (QPP) and dipeptidylpeptidase 7 (DPP7) (1, 2). It shares some substrate and cleavage specificity with DPPIV/CD26, DPP8, DPP9 and seprase/FAP (fibroblast activation protein), members of the S09 family of serine proteases. As prolyl proteases that cleave proteins and peptides after proline residues, these enzymes have high potential for drug discovery (3, 4). However, DPP7 is not a member of the S09 family, but a member of the S28 family that also includes lysosomal Pro-X carboxypeptidase/prolylcarboxypeptidase/PRCP and thymus-specific serine peptidase/PRSS16 (2). The human DPP7 precursor consists of a signal peptide (aa 1‑21) and a mature chain (aa 22‑492). The purified rhDPP7 is active against Lys‑Pro‑AMC and Lys‑Ala‑AMC. Its activity against Lys‑Pro‑AMC is approximately 10‑fold of that against Lys‑Ala‑AMC under otherwise identical conditions.

  1. Underwood, R. et al. (1999) J. Biol. Chem. 274:34053.
  2. Maes, M.B. et al. (2005) Biochem. J. 386:315.
  3. Rosenblum, J.S. and J.W. Kozarich (2003) Curr. Opin. Chem. Biol. 7:496.
  4. Lankas, G.R. et al. (2005) Diabetes 54:2988.
Long Name
Dipeptidyl-peptidase II
Entrez Gene IDs
29952 (Human); 83768 (Mouse); 83799 (Rat)
Alternate Names
carboxytripeptidase; Dipeptidyl aminopeptidase II; dipeptidyl arylamidase II; dipeptidyl peptidase 2; Dipeptidyl peptidase 7; Dipeptidyl peptidase II; dipeptidylpeptidase 7; dipeptidyl-peptidase 7; dipeptidyl-peptidase II; DPP II; DPP2; DPP7; DPPII; EC; QPP; Quiescent cell proline dipeptidase

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