Rat IgG2A Isotype Control

Name: Rat IgG2A Isotype Control
Brand: R&D Systems

(96 citations)

Datasheet / CoA / SDS

Control

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Product Details

Citations (96)

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Supplemental Products

Reviews

Specificity

Selected for use as rat IgG_2A isotype control. In direct ELISAs, does not cross-react with recombinant human (rh) 6Ckine, recombinant mouse (rm) 6Ckine, rhACT II (rhMIP-1 beta ), rhBLC/BCA-1, rmBLC, rmC10, recombinant rat (rr) CINC-1, rrCINC-2 alpha, rrCINC-2 beta, rrCINC-3, rhCK beta 8-1, recombinant viral (rv) CMV UL146, rmCRG-2, rhENA-78, rhEotaxin, rmEotaxin, rhEotaxin 2, rhEotaxin-3, rmEotaxin 2, rhFractalkine, rmFractalkine, rrFractalkine, rhGCP-2, rmGCP-2, rhGRO alpha, rhGRO beta, rhGRO gamma, rhHCC-1, rhHCC-4, rhI-309, rhIL-8, recombinant porcine IL-8, rhIP-10, rhI-TAC, rmJE, rmKC, rhLeukotactin -1, rhLymphytactin, rmLymphotactin, rmMARC, rhMCP-1, rhMCP-2, rhMCP-3, rhMCP-4, rmMCP-5, rvMCV Type 2, rhMDC, rmMDC, rhMIG, rmMIG, rhMIP-1 alpha, rmMIP-1 alpha, rmMIP-1 beta, rmMIP-1 gamma, rhMIP-1δ, rmMIP-2, rhMIP-3 alpha, rrMIP-3 alpha, rhMIP-3 beta, rmMIP-3 alpha, rmMIP-3 beta, rvMIP-I, rvMIP-II, rvMIP-III, rhMPIF-1, rhNAP-2, rhParc, rhRANTES, rmRANTES, rhSDF-1 alpha, rmSDF-1 alpha, rhSDF-1 beta, rhTarc, rmTARC, rmTCA-3, rhTeck, or rmTeck.
Source

Monoclonal Rat IgG_2A Clone # 54447
Purification

Protein A or G purified from hybridoma culture supernatant
Immunogen

KLH
Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Endotoxin Level

<0.10 EU per 1 μg of the antibody by the LAL method.
Label

Unconjugated

Product Datasheets

Product Datasheet

COA

Certificate of Analysis Lookup

Certificate of Analysis Request Form

SDS

Applications

Recommended
Concentration

Sample

Control

Negative control for use in conjunction with R&D Systems antibodies. Use at the same concentration as the detection antibody.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Example

Control

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Detection of Rat IgGControl by Flow Cytometry B16-F1 mouse melanoma cell line was stained with RatAnti-Mouse Integrin beta 1/CD29 Monoclonal Antibody (Catalog # MAB2405,filled histogram) or Rat IgG Isotype Control Antibody (Catalog #MAB006,open histogram), followed by Phycoerythrin-conjugated Anti-Rat IgG SecondaryAntibody
(Catalog # F0105B).

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IgG2A

R&D Systems offers a range of secondary antibodies and controls for flow cytometry, immunohistochemistry, and Western blotting. We provide species-specific secondary antibodies that are available with a variety of conjugated labels.

Our NorthernLights fluorescent secondary antibodies are bright and resistant to photobleaching. We are currently offering secondary antibodies recognizing mouse, rat, goat, sheep, and rabbit IgG as well as chicken IgY. These reagents are available with three distinct excitation and emission maxima, making them ideal for multi-color fluorescence microscopy.

Long Name:

Immunoglobulin G2A Fc

Alternate Names:

IgG2A

Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

96 Citations: Showing 1 - 10
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Species	Applications	Sample Type
Regulation of T(H)2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells. Authors: Leon B, Ballesteros-Tato A, Browning JL, Dunn R, Randall TD, Lund FE Nat. Immunol., 2102;13(7):681-90. Species: Mouse Sample Type: In Vivo Application: Ctrl Estrogen Deficiency Promotes Cerebral Aneurysm Rupture by Upregulation of Th17 Cells and Interleukin-17A Which Downregulates E-Cadherin Authors: BL Hoh, K Rojas, L Lin, HZ Fazal, S Hourani, KW Nowicki, MB Schneider, K Hosaka J Am Heart Assoc, 2018;7(8):. Species: Mouse Sample Type: In Vivo Application: In vivo Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth Authors: Y Shi, YF Ping, W Zhou, ZC He, C Chen, BS Bian, L Zhang, L Chen, X Lan, XC Zhang, K Zhou, Q Liu, H Long, TW Fu, XN Zhang, MF Cao, Z Huang, X Fang, X Wang, H Feng, XH Yao, SC Yu, YH Cui, X Zhang, JN Rich, S Bao, XW Bian Nat Commun, 2017;8(0):15080. Species: Human Sample Type: Whole Cells Application: Flow Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9 Authors: JA Schwartz, KL Clayton, S Mujib, H Zhang, AK Rahman, J Liu, FY Yue, E Benko, C Kovacs, MA Ostrowski J. Immunol, 2017;0(0):. Species: Human Sample Type: Whole Cells Application: Neut Role of Eosinophils and Tumor Necrosis Factor Alpha in Interleukin-25-Mediated Protection from Amebic Colitis Authors: Z Noor, K Watanabe, MM Abhyankar, SL Burgess, EL Buonomo, CA Cowardin, WA Petri MBio, 2017;8(1):. Species: Mouse Sample Type: In Vivo Application: In vivo Evaluation of F8-TNF-? in Models of Early and Progressive Metastatic Osteosarcoma Authors: B Robl, SM Botter, A Boro, D Meier, D Neri, B Fuchs Transl Oncol, 2017;10(3):419-430. Species: Mouse Sample Type: Whole Tissue Application: IHC OCT-embedded Regulatory T cells promote myelin regeneration in the central nervous system Authors: Y Dombrowski, T O'Hagan, M Dittmer, R Penalva, SR Mayoral, P Bankhead, S Fleville, G Eleftheria, C Zhao, M Naughton, R Hassan, J Moffat, J Falconer, A Boyd, P Hamilton, IV Allen, A Kissenpfen, PN Moynagh, E Evergren, B Perbal, AC Williams, RJ Ingram, JR Chan, RJ Franklin, DC Fitzgerald Nat. Neurosci, 2017;0(0):. Species: Mouse Sample Type: Whole Tissue TPL-2 restricts Ccl24-dependent immunity to Heligmosomoides polygyrus Authors: Y Kannan, LJ Entwistle, VS Pelly, J Perez-Llor, AW Walker, SC Ley, MS Wilson PLoS Pathog., 2017;13(7):e1006536. Species: Mouse Sample Type: In Vivo Microbiome-mediated neutrophil recruitment via CXCR2 and protection from amebic colitis Authors: K Watanabe, CA Gilchrist, MJ Uddin, SL Burgess, MM Abhyankar, SN Moonah, Z Noor, JR Donowitz, BN Schneider, T Arju, E Ahmed, M Kabir, M Alam, R Haque, P Pramoonjag, B Mehrad, WA Petri PLoS Pathog., 2017;13(8):e1006513. Species: Mouse Sample Type: In Vivo Application: Neut MiR-497?195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1? activity Authors: M Yang, CJ Li, X Sun, Q Guo, Y Xiao, T Su, ML Tu, H Peng, Q Lu, Q Liu, HB He, TJ Jiang, MX Lei, M Wan, X Cao, XH Luo Nat Commun, 2017;8(0):16003. Species: Mouse Sample Type: Whole Tissue Application: IHC Therapeutic Effectiveness of Anti-RAGE Antibody Administration in a Rat Model of Crush Injury Authors: H Matsumoto, N Matsumoto, J Shimazaki, J Nakagawa, Y Imamura, K Yamakawa, T Yamada, M Ikeda, H Hiraike, H Ogura, T Shimazu Sci Rep, 2017;7(1):12255. Species: Rat Sample Type: Whole Tissue Application: IHC FGF23 expression in rodents is directly induced via erythropoietin after inhibition of hypoxia inducible factor proline hydroxylase Authors: I Flamme, P Ellinghaus, D Urrego, T Krüger PLoS ONE, 2017;12(10):e0186979. Species: Rat Sample Type: In Vivo Application: Ctrl p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis Authors: A Okuma, A Hanyu, S Watanabe, E Hara Nat Commun, 2017;8(1):2050. Species: Mouse Sample Type: In Vivo Application: In Vivo CCL19-CCR7-dependent reverse transendothelial migration of myeloid cells clears Chlamydia muridarum from the arterial intima Nat Immunol, 2016;0(0):. Species: Mouse Sample Type: In Vivo Application: Neut Allostimulatory Effects of Dendritic Cells with Characteristic Features of a Regulatory Phenotype PLoS ONE, 2016;11(8):e0159986. Species: Mouse Sample Type: Whole Cells Application: Bioassay Ctrl IL-17A Is an Important Effector of the Immune Response of the Mammary Gland to Escherichia coli Infection. Authors: Porcherie A, Gilbert F, Germon P, Cunha P, Trotereau A, Rossignol C, Winter N, Berthon P, Rainard P J Immunol, 2016;196(2):803-12. Species: Mouse Sample Type: Whole Cells Application: Neut Ctrl Thymic Stromal Lymphopoietin Neutralization Inhibits the Immune Adjuvant Effect of Di-(2-Ethylhexyl) Phthalate in Balb/c Mouse Asthma Model PLoS ONE, 2016;11(7):e0159479. Species: Mouse Sample Type: In Vivo Application: Ctrl Neutrophils suppress intraluminal NK-mediated tumor cell clearance and enhance extravasation of disseminated carcinoma cells Authors: A Spiegel, MW Brooks, S Houshyar, F Reinhardt, M Ardolino, E Fessler, MB Chen, JA Krall, J DeCock, IK Zervantona, A Iannello, Y Iwamoto, V Cortez-Ret, RD Kamm, MJ Pittet, DH Raulet, RA Weinberg Cancer Discov, 2016;0(0):. Species: Mouse Sample Type: In Vivo Application: In Vivo Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair Authors: Jennifer Quantius PLoS Pathog, 2016;12(6):e1005544. Species: Mouse Sample Type: Tissue Homogenates Application: Flow NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo J Immunol, 2016;196(11):4805-13. Species: Mouse Sample Type: Whole Cells Application: Flow Seminal plasma induces inflammation in the uterus through the ?? T/IL-17 pathway Authors: ZH Song, ZY Li, DD Li, WN Fang, HY Liu, DD Yang, CY Meng, Y Yang, JP Peng Sci Rep, 2016;6(0):25118. Species: Mouse Sample Type: In Vivo Application: In vivo Gliotoxin Suppresses Macrophage Immune Function by Subverting Phosphatidylinositol 3,4,5-Trisphosphate Homeostasis Authors: D Schlam, J Canton, M Carreño, H Kopinski, SA Freeman, S Grinstein, GD Fairn MBio, 2016;7(2):. Species: Mouse Sample Type: Whole Cells Application: Flow A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice Nat Commun, 2016;7(0):13896. Species: Mouse Sample Type: Whole Cells Application: Flow Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway J Neuroinflammation, 2016;13(1):209. Species: Mouse Sample Type: In Vivo Application: In vivo control Basophils promote tumor rejection via chemotaxis and infiltration of CD8+ T cells Cancer Res., 2016;0(0):. Species: Mouse Sample Type: In Vivo The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin Nat. Immunol., 2016;0(0):. Species: Mouse Sample Type: In Vivo Application: In vivo A Herpesviral induction of RAE-1 NKG2D ligand expression occurs through release of HDAC mediated repression Elife, 2016;5(0):. Species: Mouse Sample Type: Whole Cells Application: Flow Targeting GM-CSF in epithelial and vascular remodeling in experimental Eosinophilic Esophagitis Authors: Eóin N McNamee Allergy, 2016;0(0):. Species: Mouse Sample Type: In Vivo Application: In Vivo Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD Authors: Hoeke A Baarsma J. Exp. Med, 2016;0(0):. Species: Mouse Sample Type: In Vivo Application: Ctrl Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy. Authors: Barreira da Silva R, Laird M, Yatim N, Fiette L, Ingersoll M, Albert M Nat Immunol, 2015;16(8):850-8. Species: Mouse Sample Type: In Vivo Application: Neut Static stretch affects neural stem cell differentiation in an extracellular matrix-dependent manner. Authors: Arulmoli J, Pathak M, McDonnell L, Nourse J, Tombola F, Earthman J, Flanagan L Sci Rep, 2015;5(0):8499. The calcineurin-NFAT axis controls allograft immunity in myeloid-derived suppressor cells through reprogramming T cell differentiation. Authors: Wang X, Bi Y, Xue L, Liao J, Chen X, Lu Y, Zhang Z, Wang J, Liu H, Yang H, Liu G Mol Cell Biol, 2015;35(3):598-609. Species: Mouse Sample Type: In Vivo Application: Neut Immune complexes regulate bone metabolism through FcRgamma signalling. Authors: Negishi-Koga T, Gober H, Sumiya E, Komatsu N, Okamoto K, Sawa S, Suematsu A, Suda T, Sato K, Takai T, Takayanagi H Nat Commun, 2015;6(0):6637. Species: Mouse Sample Type: Whole Cells Application: Flow Dendritic Cells Regulate Treg-Th17 Axis in Obstructive Phase of Bile Duct Injury in Murine Biliary Atresia. Authors: Liu Y, Li K, Yang L, Tang S, Wang X, Cao G, Li S, Lei H, Zhang X PLoS ONE, 2015;10(9):e0136214. Species: Mouse Sample Type: In Vivo Application: Neut Ctrl Tumor-induced pressure in the bone microenvironment causes osteocytes to promote the growth of prostate cancer bone metastases. Authors: Sottnik J, Dai J, Zhang H, Campbell B, Keller E Cancer Res, 2015;75(11):2151-8. Species: Human Sample Type: Whole Cells Application: Neut Ctrl Neonatal Streptococcus pneumoniae infection may aggravate adulthood allergic airways disease in association with IL-17A. Authors: Yang B, Liu R, Yang T, Jiang X, Zhang L, Wang L, Wang Q, Luo Z, Liu E, Fu Z PLoS ONE, 2015;10(3):e0123010. Species: Mouse Sample Type: In Vivo Application: Neut Ctrl Critical role for IL-18 in spontaneous lung inflammation caused by autophagy deficiency. Authors: Abdel Fattah E, Bhattacharya A, Herron A, Safdar Z, Eissa N J Immunol, 2015;194(11):5407-16. Species: Mouse Sample Type: In Vivo Application: Neut Ctrl NADPH oxidase-independent formation of extracellular DNA traps by basophils. Authors: Morshed M, Hlushchuk R, Simon D, Walls A, Obata-Ninomiya K, Karasuyama H, Djonov V, Eggel A, Kaufmann T, Simon H, Yousefi S J Immunol, 2014;192(11):5314-23. Species: Mouse Sample Type: Whole Cells Application: Isotype control IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice. Authors: Guabiraba R, Besnard A, Menezes G, Secher T, Jabir M, Amaral S, Braun H, Lima-Junior R, Ribeiro R, Cunha F, Teixeira M, Beyaert R, Graham G, Liew F Mucosal Immunol, 2014;7(5):1079-93. Species: Mouse Sample Type: In Vivo Application: In vivo Syndecan-1 in the mouse parietal peritoneum microcirculation in inflammation. Authors: Kowalewska P, Patrick A, Fox-Robichaud A PLoS ONE, 2014;9(9):e104537. Species: Mouse Sample Type: In Vivo Application: IHC Fresh Eosinophils promote generation and maintenance of immunoglobulin-A-expressing plasma cells and contribute to gut immune homeostasis. Authors: Chu V, Beller A, Rausch S, Strandmark J, Zanker M, Arbach O, Kruglov A, Berek C Immunity, 2014;40(4):582-93. Species: Mouse Sample Type: In Vivo Application: In vivo Nitric oxide regulates BAFF expression and T cell-independent antibody responses. Authors: Giordano D, Draves K, Li C, Hohl T, Clark E J Immunol, 2014;193(3):1110-20. Species: Mouse Sample Type: Whole Cells Application: Flow The role of host and microbial factors in the pathogenesis of pneumococcal bacteraemia arising from a single bacterial cell bottleneck. Authors: Gerlini A, Colomba L, Furi L, Braccini T, Manso A, Pammolli A, Wang B, Vivi A, Tassini M, Van Rooijen N, Pozzi G, Ricci S, Andrew P, Koedel U, Moxon E, Oggioni M PLoS Pathog, 2014;10(3):e1004026. Species: Mouse Sample Type: Whole Cells Application: Flow CCR6 is a prognostic marker for overall survival in patients with colorectal cancer, and its overexpression enhances metastasis in vivo. Authors: Liu, Jinlin, Ke, Fang, Xu, Zhenyao, Liu, Zhaoyuan, Zhang, Lingyun, Yan, Sha, Wang, Zhe, Wang, Hong, Wang, Honglin PLoS ONE, 2014;9(6):e101137. Species: Mouse Sample Type: In Vivo Application: In vivo MULT1E/mIL-12: a novel bifunctional protein for natural killer cell activation. Authors: Tietje A, Li J, Yu X, Wei Y Gene Ther, 2014;21(5):468-75. Species: Mouse Sample Type: Cell Culture Supernates Application: ELISA Development Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil- and CCL8-dependent manner. Authors: Dulek D, Newcomb D, Goleniewska K, Cephus J, Zhou W, Reiss S, Toki S, Ye F, Zaynagetdinov R, Sherrill T, Blackwell T, Moore M, Boyd K, Kolls J, Peebles R Infect Immun, 2014;82(9):3723-39. Species: Mouse Sample Type: In Vivo Application: In vivo Interleukin-17A modulates circulating tumor cells in tumor draining vein of colorectal cancers and affects metastases. Authors: Tseng J, Yang C, Liang S, Liu R, Yang S, Lin J, Chen Y, Wu Y, Jiang J, Lin C Clin Cancer Res, 2014;20(11):2885-97. Species: Mouse Sample Type: In Vivo Application: In vivo gammadelta T cells are required for pulmonary IL-17A expression after ozone exposure in mice: role of TNFalpha. Authors: Mathews J, Williams A, Brand J, Wurmbrand A, Chen L, Ninin F, Si H, Kasahara D, Shore S PLoS ONE, 2014;9(5):e97707. Species: Mouse Sample Type: In Vivo Application: In vivo Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells. Authors: Yokota-Nakatsuma A, Takeuchi H, Ohoka Y, Kato C, Song S, Hoshino T, Yagita H, Ohteki T, Iwata M Mucosal Immunol, 2014;7(4):786-801. Species: Mouse Sample Type: Whole Cells Application: Isotype control mTOR limits the recruitment of CD11b+Gr1+Ly6Chigh myeloid-derived suppressor cells in protecting against murine immunological hepatic injury. Authors: Zhang Y, Bi Y, Yang H, Chen X, Liu H, Lu Y, Zhang Z, Liao J, Yang S, Chu Y, Yang R, Liu G J Leukoc Biol, 2014;95(6):961-70. Species: Mouse Sample Type: In Vivo Application: In vivo Interleukin-33 and alveolar macrophages contribute to the mechanisms underlying the exacerbation of IgE-mediated airway inflammation and remodelling in mice. Authors: Mizutani N, Nabe T, Yoshino S Immunology, 2013;139(2):205-18. Species: Mouse Sample Type: In Vivo Application: Isotype control Galectin-9 functionally impairs natural killer cells in humans and mice. Authors: Golden-Mason L, McMahan R, Strong M, Reisdorph R, Mahaffey S, Palmer B, Cheng L, Kulesza C, Hirashima M, Niki T, Rosen H J Virol, 2013;87(9):4835-45. Species: Human Sample Type: Whole Cells Application: Neut Differential role of lipocalin 2 during immune complex-mediated acute and chronic inflammation in mice. Authors: Shashidharamurthy R, Machiah D, Aitken J, Putty K, Srinivasan G, Chassaing B, Parkos C, Selvaraj P, Vijay-Kumar M Arthritis Rheum, 2013;65(4):1064-73. Species: Mouse Sample Type: Engagement of two distinct binding domains on CCL17 is required for signaling through CCR4 and establishment of localized inflammatory conditions in the lung. Authors: Santulli-Marotto S, Boakye K, Lacy E, Wu S, Luongo J, Kavalkovich K, Coelho A, Hogaboam C, Ryan M PLoS ONE, 2013;8(12):e81465. Species: Mouse Sample Type: Recombinant Protein Application: Bioassay CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitis. Authors: Roy M, Richard JF, Dumas A, Vallieres L J Neuroinflammation, 2012;9(0):18. Species: Mouse Sample Type: In Vivo Application: Ctrl Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma. Authors: Blotta, Simona, Jakubikova, Jana, Calimeri, Teresa, Roccaro, Aldo M, Amodio, Nicola, Azab, Abdel Ka, Foresta, Umberto, Mitsiades, Constant, Rossi, Marco, Todoerti, Katia, Molica, Stefano, Morabito, Fortunat, Neri, Antonino, Tagliaferri, Piersand, Tassone, Pierfran, Anderson, Kenneth, Munshi, Nikhil C Blood, 2012;120(25):5002-13. Species: Human Sample Type: Whole Cells Application: Flow control Inducible IL-33 expression by mast cells is regulated by a calcium-dependent pathway. Authors: Hsu C, Bryce P J Immunol, 2012;189(7):3421-9. Species: Mouse Sample Type: Whole Cells Application: Ctrl Respiratory syncytial virus reverses airway hyperresponsiveness to methacholine in ovalbumin-sensitized mice. Authors: Aeffner F, Davis I PLoS ONE, 2012;7(10):e46660. Species: Mouse Sample Type: In Vivo Application: Ctrl Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells. Authors: Islam SA, Chang DS, Colvin RA Nat. Immunol., 2011;12(2):167-77. Species: Mouse Sample Type: In Vivo Application: Ctrl TNF-alpha promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines. Authors: Zhao C, Sardella A, Chun J, Poubelle PE, Fernandes MJ, Bourgoin SG J. Lipid Res., 2011;52(7):1307-18. Species: Mouse Sample Type: In Vivo Application: Ctrl The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Authors: Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, Lucin KM, Czirr E, Park JS, Couillard-Despres S, Aigner L, Li G, Peskind ER, Kaye JA, Quinn JF, Galasko DR, Xie XS, Rando TA, Wyss-Coray T Nature, 2011;477(7362):90-4. Species: Mouse Sample Type: In Vivo Application: Ctrl IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung. Authors: Khader SA, Guglani L, Rangel-Moreno J J. Immunol., 2011;187(10):5402-7. Species: Mouse Sample Type: In Vivo Application: Ctrl Patched1 inhibits epidermal progenitor cell expansion and basal cell carcinoma formation by limiting Igfbp2 activity. Authors: Villani RM, Adolphe C, Palmer J, Waters MJ, Wainwright BJ Cancer Prev Res (Phila), 2010;3(10):1222-34. Species: Mouse Sample Type: Whole Tissue Application: Ctrl IL-33 is produced by mast cells and regulates IgE-dependent inflammation. Authors: Hsu CL, Neilsen CV, Bryce PJ PLoS ONE, 2010;5(8):e11944. Species: Mouse Sample Type: Whole Cells Application: Ctrl IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis. Authors: Lo Re S, Dumoutier L, Couillin I, Van Vyve C, Yakoub Y, Uwambayinema F, Marien B, van den Brule S, Van Snick J, Uyttenhove C, Ryffel B, Renauld JC, Lison D, Huaux F J. Immunol., 2010;184(11):6367-77. Species: Mouse Sample Type: In Vivo Application: Ctrl Molecular immune responses to aerosol challenge with Francisella tularensis in mice inoculated with live vaccine candidates of varying efficacy. Authors: Shen H, Harris G, Chen W, Sjostedt A, Ryden P, Conlan W PLoS ONE, 2010;5(10):e13349. Species: Mouse Sample Type: In Vivo Application: Ctrl Innate immune activation during Salmonella infection initiates extramedullary erythropoiesis and splenomegaly. Authors: Jackson A, Nanton MR, O'Donnell H J. Immunol., 2010;185(10):6198-204. Species: Mouse Sample Type: In Vivo Application: Ctrl Protective role of interleukin-17 in murine NKT cell-driven acute experimental hepatitis. Authors: Wondimu Z, Santodomingo-Garzon T, Le T, Swain MG Am. J. Pathol., 2010;177(5):2334-46. Species: Mouse Sample Type: In Vivo Application: Ctrl Dynamic macrophage "probing" is required for the efficient capture of phagocytic targets. Authors: Flannagan RS, Harrison RE, Yip CM, Jaqaman K, Grinstein S J. Cell Biol., 2010;191(6):1205-18. Species: Mouse Sample Type: Application: Flow control Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease. Authors: Horvat JC, Starkey MR, Kim RY, Beagley KW, Preston JA, Gibson PG, Foster PS, Hansbro PM J. Immunol., 2010;184(8):4159-69. Species: Mouse Sample Type: In Vivo Application: Ctrl A critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mice. Authors: Gao Q, Jiang Y, Ma T, Zhu F, Gao F, Zhang P, Guo C, Wang Q, Wang X, Ma C, Zhang Y, Chen W, Zhang L J. Immunol., 2010;185(10):5820-7. Species: Mouse Sample Type: In Vivo Application: Ctrl Absence of functional Hfe protects mice from invasive Salmonella enterica serovar Typhimurium infection via induction of lipocalin-2. Authors: Nairz M, Theurl I, Schroll A, Theurl M, Fritsche G, Lindner E, Seifert M, Crouch ML, Hantke K, Akira S, Fang FC, Weiss G Blood, 2009;114(17):3642-51. Species: Mouse Sample Type: Serum Application: Ctrl Junctional adhesion molecule (JAM)-B supports lymphocyte rolling and adhesion through interaction with alpha4beta1 integrin. Authors: Ludwig RJ, Hardt K, Hatting M, Bistrian R, Diehl S, Radeke HH, Podda M, Schon MP, Kaufmann R, Henschler R, Pfeilschifter JM, Santoso S, Boehncke WH Immunology, 2009;128(2):196-205. Species: Mouse Sample Type: In Vivo Application: Ctrl Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production. Authors: Lemos HP, Grespan R, Vieira SM, Cunha TM, Verri WA, Fernandes KS, Souto FO, McInnes IB, Ferreira SH, Liew FY, Cunha FQ Proc. Natl. Acad. Sci. U.S.A., 2009;106(14):5954-9. Species: Mouse Sample Type: Whole Cells Application: Ctrl IL-17/Th17 promotes type 1 T cell immunity against pulmonary intracellular bacterial infection through modulating dendritic cell function. Authors: Bai H, Cheng J, Gao X, Joyee AG, Fan Y, Wang S, Jiao L, Yao Z, Yang X J. Immunol., 2009;183(9):5886-95. Species: Mouse Sample Type: In Vivo Application: Ctrl TREM-1 activation alters the dynamics of pulmonary IRAK-M expression in vivo and improves host defense during pneumococcal pneumonia. Authors: Lagler H, Sharif O, Haslinger I, Matt U, Stich K, Furtner T, Doninger B, Schmid K, Gattringer R, de Vos AF, Knapp S J. Immunol., 2009;183(3):2027-36. Species: Mouse Sample Type: In Vivo Application: Ctrl Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines. Authors: St John AL, Abraham SN Nat. Med., 2009;15(11):1259-65. Species: Mouse Sample Type: In Vivo Application: Ctrl A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Authors: Wu S, Rhee KJ, Albesiano E, Rabizadeh S, Wu X, Yen HR, Huso DL, Brancati FL, Wick E, McAllister F, Housseau F, Pardoll DM, Sears CL Nat. Med., 2009;15(9):1016-22. Species: Mouse Sample Type: In Vivo Application: Ctrl Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC. Authors: Inagaki A, Ishida T, Yano H, Ishii T, Kusumoto S, Ito A, Ri M, Mori F, Ding J, Komatsu H, Iida S, Ueda R Int. J. Cancer, 2009;125(1):212-21. Encephalitogenicity of complete Freund's adjuvant relative to CpG is linked to induction of Th17 cells. Authors: Tigno-Aranjuez JT, Jaini R, Tuohy VK, Lehmann PV, Tary-Lehmann M J. Immunol., 2009;183(9):5654-61. Species: Mouse Sample Type: In Vivo Application: Ctrl A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum. Authors: Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G J. Immunol., 2009;183(2):1291-300. Species: Mouse Sample Type: In Vivo Application: Ctrl A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation. Authors: Boehme SA, Franz-Bacon K, Chen EP, Sasik R, Sprague LJ, Ly TW, Hardiman G, Bacon KB Int. Immunol., 2009;21(1):81-93. Species: Mouse Sample Type: In Vivo Application: Ctrl Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. Authors: D'Angelo C, Segal BH Nature, 2008;451(7175):211-5. Species: Mouse Sample Type: In Vivo Application: Ctrl Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection. Authors: Bozza S, Zelante T, Moretti S, Bonifazi P, DeLuca A, D'Angelo C, Giovannini G, Garlanda C, Boon L, Bistoni F, Puccetti P, Mantovani A, Romani L J. Immunol., 2008;180(6):4022-31. Species: Mouse Sample Type: In Vivo Application: Ctrl iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity. Authors: Meyer EH, Wurbel MA, Staton TL, Pichavant M, Kan MJ, Savage PB, DeKruyff RH, Butcher EC, Campbell JJ, Umetsu DT J. Immunol., 2007;179(7):4661-71. Species: Mouse Sample Type: Whole Cells Application: Ctrl Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge. Authors: He R, Oyoshi MK, Jin H, Geha RS Proc. Natl. Acad. Sci. U.S.A., 2007;104(40):15817-22. Species: Mouse Sample Type: In Vivo Application: Ctrl IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. Authors: Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA J. Immunol., 2007;178(4):2018-27. Species: Mouse Sample Type: Whole Cells Application: Ctrl Anti-type II collagen antibody accelerates arthritis via CXCR2-expressing cells in IL-1 receptor antagonist-deficient mice. Authors: Kagari T, Tanaka D, Doi H, Iwakura Y, Shimozato T Eur. J. Immunol., 2007;37(10):2753-63. Species: Mouse Sample Type: In Vivo Application: Ctrl Excreted urinary mediators in an animal model of experimental immune nephritis with potential pathogenic significance. Authors: Wu T, Xie C, Bhaskarabhatla M, Yan M, Leone A, Chen SS, Zhou XJ, Putterman C, Mohan C Arthritis Rheum., 2007;56(3):949-59. Species: Mouse Sample Type: In Vivo Application: Ctrl Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1. Authors: Carlson EC, Lin M, Liu CY, Kao WW, Perez VL, Pearlman E J. Biol. Chem., 2007;282(49):35502-9. Species: Mouse Sample Type: Tissue Homogenates Application: Ctrl A role for activation-induced cytidine deaminase in the host response against a transforming retrovirus. Authors: Gourzi P, Leonova T, Papavasiliou FN Immunity, 2006;24(6):779-86. Species: Mouse Sample Type: Whole Cells Application: Ctrl TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells. Authors: Higgins SC, Jarnicki AG, Lavelle EC, Mills KH J. Immunol., 2006;177(11):7980-9. Species: Mouse Sample Type: In Vivo Application: Ctrl Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines. Authors: Gounni Abdelilah S, Wellemans V, Agouli M, Guenounou M, Hamid Q, Beck LA, Lamkhioued B Clin. Immunol., 2006;120(2):220-31. Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion. Authors: Spencer LA, Melo RC, Perez SA, Bafford SP, Dvorak AM, Weller PF Proc. Natl. Acad. Sci. U.S.A., 2006;103(9):3333-8. Species: Human Sample Type: Whole Cells Application: Ctrl A new RXR agonist, HX630, suppresses intimal hyperplasia in a mouse blood flow cessation model. Authors: Haraguchi G, Suzuki J, Kosuge H, Ogawa M, Koga N, Muto S, Itai A, Kagechika H, Shudo K, Isobe M J. Mol. Cell. Cardiol., 2006;41(5):885-92. Species: Mouse Sample Type: Whole Tissue Application: Ctrl Rapid up-regulation of CXC chemokines in the airways after Ag-specific CD4+ T cell activation. Authors: Knott PG, Gater PR, Dunford PJ, Fuentes ME, Bertrand CP J. Immunol., 2001;166(2):1233-40. Species: Mouse Sample Type: In Vivo Application: Ctrl Expand to show all Citations

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Isotype Controls

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Rat IgG2A PE-conjugated Antibody

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Rat IgG2A Allophycocyanin Isotype Control

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Rat IgG2A Alexa Fluor® 488‑conjugated Isotype Control

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Rat IgG2A Fluorescein-conjugated Antibody

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Rat IgG2A Alexa Fluor® 647-conjugated Antibody

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