Human E-Cadherin PE-conjugated Antibody
Human E-Cadherin PE-conjugated Antibody Summary
Asp155-Ile707
Accession # P12830
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Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of E-Cadherin in MCF-7 Human Cell Line by Flow Cytometry.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: E-Cadherin
Epithelial (E)‑Cadherin (ECAD), also known as Cadherin-1, cell-CAM120/80 in the human, uvomorulin in the mouse, Arc-1 in the dog, and L-CAM in the chicken, is a member of the Cadherin family of cell adhesion molecules (gene name CDH1). Cadherins are calcium-dependent transmembrane proteins which bind to one another in a homophilic manner. On their cytoplasmic side, they associate with the three catenins, alpha, beta, and gamma (plakoglobin). This association links the cadherin protein to the cytoskeleton. Without association with the catenins, the cadherins are non-adhesive. Cadherins play a role in development, specifically in tissue formation. They may also help to maintain tissue architecture in the adult. E-Cadherin may also play a role in tumor development, as loss of E-Cadherin has been associated with tumor invasiveness. E-Cadherin is a classical cadherin molecule. Classical cadherins consist of a large extracellular domain which contains DXD and DXNDN repeats responsible for mediating calcium‑dependent adhesion, a single-pass transmembrane domain, and a short carboxy-terminal cytoplasmic domain responsible for interacting with the catenins. E‑Cadherin contains five extracellular calcium-binding domains of approximately 110 amino acids each (amino acids 155-697).
- Bussemakers, M.J.G. et al. (1993) Mol. Biol. Reports 17:123.
- Overduin, M. et al. (1995) Science 267:386.
- Takeichi, M. (1991) Science 251:1451.
Product Datasheets
Citations for Human E-Cadherin PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 3
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Cell-based selection provides novel molecular probes for cancer stem cells.
Authors: Sefah K, Bae K, Phillips J, Siemann D, Su Z, McClellan S, Vieweg J, Tan W
Int J Cancer, 2013;132(11):2578-88.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Interleukin-15 plays a central role in human kidney physiology and cancer through the gamma c signaling pathway.
Authors: Giron-Michel J, Azzi S, Khawam K, Mortier E, Caignard A, Devocelle A, Ferrini S, Croce M, Francois H, Lecru L, Charpentier B, Chouaib S, Azzarone B, Eid P
PLoS ONE, 2012;7(2):e31624.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Human embryonic stem cells with maintenance under a feeder-free and recombinant cytokine-free condition.
Authors: Nakahara M, Saeki K, Nakamura N
Cloning Stem Cells, 2009;11(1):5-18.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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