Human ETV5 Alexa Fluor® 488-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: ETV5

ETS translocation variant 5 (ETV5), also known as ERM, is an approximately 70 kDa member of the ETS transcription factor family. The expression of ETV5 in Sertoli, granulosa, and cumulus cells is important for the ability of these cells to support spermatogonia stem cell and oocyte development. ETV5 is upregulated at the invasive front of various carcinomas, and it plays a role in tumor cell invasiveness. It is a target of chromosomal translocation in prostate cancer and forms a fusion protein with TMPRSS2. It is also required for branching morphogenesis during early kidney development. ETV5 contains a single Ets DNA-binding domain (aa 367-452). Within aa 119-223, human ETV5 shares 92% aa sequence identity with mouse and rat ETV5.

Product Datasheets

Related Research Areas

• ETS Family Transcription Factors
• Mesenchymal Stem Cell Transcription Factors