Human ETV5 Antibody Summary
Accession # P41161
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
ETV5 in BT‑20 Human Cell Line. ETV5 was detected in immersion fixed BT-20 human breast cancer cell line using Mouse Anti-Human ETV5 Monoclonal Antibody (Catalog # MAB7107) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red, upper panel; Catalog # NL007) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
ETS translocation variant 5 (ETV5), also known as ERM, is an approximately 70 kDa member of the ETS transcription factor family. The expression of ETV5 in Sertoli, granulosa, and cumulus cells is important for the ability of these cells to support spermatogonia stem cell and oocyte development. ETV5 is upregulated at the invasive front of various carcinomas, and it plays a role in tumor cell invasiveness. It is a target of chromosomal translocation in prostate cancer and forms a fusion protein with TMPRSS2. It is also required for branching morphogenesis during early kidney development. ETV5 contains a single Ets DNA-binding domain (aa 367-452). Within aa 119-223, human ETV5 shares 92% aa sequence identity with mouse and rat ETV5.
Citation for Human ETV5 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
Dynamics of chromatin accessibility during TGF-?-induced EMT of Ras-transformed mammary gland epithelial cells
Authors: M Arase, Y Tamura, N Kawasaki, K Isogaya, R Nakaki, A Mizutani, S Tsutsumi, H Aburatani, K Miyazono, D Koinuma
Sci Rep, 2017;7(1):1166.
Sample Types: Whole Cells
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