IL-23 p19 (Interleukin 23 p19; also IL-23 alpha) is an 18-20 kDa (estimated) member of the IL-6 superfamily of molecules. It is disulfide-bonded to p40 to form IL-23. IL-23 is secreted by immune-related cell types such as keratinocytes, dendritic cells, macrophages, microglia and monocytes, often following TLR stimulation. It appears to drive Th17 cell development by inhibiting T-bet and FoxP3 production, and to reduce IL-12-mediated IFN-gamma production by CD4+, CD8+ and NK cells. Based on human, mature feline IL-23 p19 is 160 amino acids (aa) in length. It is a alpha -helical molecule that utilizes Cys80 to form an interchain disulfide bond with IL-12 p40. IL-23 p19 does not appear to be released unless dimerized to p40. There are no potential N-linked glycosylation sites on p19. Mature feline IL-23 p19 (aa 26-185) shares 87% aa identity with human IL-23 p19.
Human/Feline IL‑23 p19 Alexa Fluor™ Plus 405‑conjugated Antibody
R&D Systems | Catalog # AF6238AFP405
Key Product Details
Species Reactivity
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Product Specifications
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Applications for Human/Feline IL‑23 p19 Alexa Fluor™ Plus 405‑conjugated Antibody
Western Blot
Formulation, Preparation, and Storage
Formulation
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Background: IL-23
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UniProt
Additional IL-23 Products
Product Documents for Human/Feline IL‑23 p19 Alexa Fluor™ Plus 405‑conjugated Antibody
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Product Specific Notices for Human/Feline IL‑23 p19 Alexa Fluor™ Plus 405‑conjugated Antibody
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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