Human IKK epsilon Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: IKK epsilon

I kappa B kinase epsilon (IKK epsilon ) is also known as IKBKE and IKKi. The classical active IKK complex, composed of IKK alpha, IKK beta, and two forms of processed IKK gamma, phosphorylates and inactivates I kappa B, resulting in the release and nuclear translocation of active NF-kappa B. IKK epsilon is an IKK-related kinase with 30% structural homology to IKK alpha and beta, and is present in a subset of IKK complexes. IKK epsilon activation has been implicated in the initiation of anti-viral gene expression and in the pathogenesis of breast cancer.

Product Datasheets

Related Research Areas

• C-type Lectin Receptors
• IL-1 Family
• IL-17 Family
• Intracellular Kinases
• Intracellular Kinases in the Akt Pathway
• Natural Killer T (NKT) Cells
• NFkB Pathway
• NOD-like Receptors and the Inflammasome
• Notch Pathway
• Positive Regulators of the Jak/STAT Pathway
• RIG-I-like Receptors
• Search Kinases and Phosphatases
• Toll-Like Receptors
• Transcription Regulators in Endothelial Cells