Human IL-4I1 Antibody

Catalog # Availability Size / Price Qty
MAB56841-100
MAB56841-SP

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Human IL-4I1 Antibody Summary

Species Reactivity
Human
Specificity
Detects human IL-4I1 in direct ELISAs.
Source
Monoclonal Rat IgG2B Clone # 1006209
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human IL-4I1
Met1-His567
Accession # Q96RQ9
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
ELISA

This antibody functions as an ELISA detection antibody when paired with Rat Anti-Human IL‑4I1 Monoclonal Antibody (Catalog # MAB56842).

This product is intended for assay development on various assay platforms requiring antibody pairs.

 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IL-4I1

Interleukin 4 induced protein 1 (IL-4I1), also known as protein FIG-1 and L-amino acid oxidase, is encoded by a B-cell IL-4-inducible gene, FIG1, and is highly expressed in primary metastinal B-cell lymphomas (1-4). It belongs to the flavin monoamine oxidase family, FIG1 subfamily. Enzymological characterization reveals that IL-4I1 has L-amino acid oxidase activity with preference toward aromatic amino acids. Studies have shown that hIL-4I1 inhibited the proliferation of CD3‑stimulated T lymphocytes with a similar effect on CD4(+) and CD8(+) T cells (5). Its inhibitory effect was dependent on enzymatic activity and H2O2 production. Its restricted expression to lymphoid tissues indicates that it may play an important function in the immune system (1, 4).

References
  1. Chu, C.C. and W.E. Paul. (1997) Proc. Natl. Acad. Sci. USA 94:2507.
  2. Mason, J.M. et al. (2004) J. Immunol. 173:4561.
  3. Chavan, S.S. et al. (2002) Biochim. Biophys. Acta. 1576:70.
  4. Copie-Bergman, C. et al. (2003) Blood 101:2756.
  5. Boulland, M.L. et al. (2007) Blood 110:220.
Long Name
Interleukin 4-induced Protein-1
Entrez Gene IDs
259307 (Human); 14204 (Mouse); 308575 (Rat); 102115096 (Cynomolgus Monkey)
Alternate Names
Fig-1 protein; FIG1; hFIG1; IL4I1; IL-4I1; IL4-induced protein 1; interleukin 4 induced 1; interleukin four induced 1; LAAO; L-amino-acid oxidase; LAO; UNQ636/PRO1265

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