Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Flow Cytometry

Cited:

Flow Cytometry

Label

Allophycocyanin (Excitation = 620-650 nm, Emission = 660-670 nm)

Antibody Source

Monoclonal Mouse IgG1 Clone # 745201
View all Integrin alpha 2b/CD41 Primary Antibodies »

Product Specifications

Immunogen

heterodimer of human Integrin alpha 2B (Leu32-Arg993; R887L) Accession P08514 + human Integrin beta 3 (Gly27-Asp718) Accession P05106

Specificity

Detects human Integrin alpha 2b/CD41 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human Integrin alpha 5, alpha 8, alpha V, beta 3, beta 5, beta 6, recombinant mouse Integrin beta 2b or beta 3 is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Human Integrin  alpha 2b/CD41 APC‑conjugated Antibody

Detection of Integrin a2b/CD41 antibody in Human Blood Platelets antibody by Flow Cytometry.

Detection of Integrin alpha 2b/CD41 in Human Blood Platelets by Flow Cytometry.

Human peripheral blood platelets were stained with FITC-conjugated Anti-Human Integrin a2b/CD41 Antibody (Clone P2) and either (A) Mouse Anti-Human Integrin a2b/CD41 APC-conjugated Monoclonal Antibody (Catalog # FAB7616A) or (B) Mouse IgG1Allophycocyanin Isotype Control (Catalog # IC002A). FAB7616A stains the same population as Clone P2. View our protocol for Staining Membrane-associated Proteins.

Detection of Integrin  alpha 2b/CD41 in Human Platelets by Flow Cytometry

Human Platelets were stained with Mouse Anti-Human Integrin  alpha 2b/CD41 APC‑conjugated Monoclonal Antibody (Catalog # FAB7616A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.

Applications for Human Integrin  alpha 2b/CD41 APC‑conjugated Antibody

Application
Recommended Usage

Flow Cytometry

10 µL/106 cells
Sample: Human peripheral blood platelets

Spectra Viewer

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

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Spectra Viewer

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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: Integrin alpha 2b/CD41

Integrin alpha 2b (ITGA2b), also known as CD41 and GPIIb, is a transmembrane glycoprotein that is expressed by megakaryocytes and platelets. It is cleaved into two disulfide-linked chains (114 kDa and 22 kDa) during transit through the Golgi. Integrin alpha 2b associates with Integrin beta 3 to form complexes that interact with Fibrinogen, von Willebrand factor, Fibronectin, and Vitronectin. Integrin alpha 2b is required for platelet aggregation, and defects lead to disorders of coagulation. Within the extracellular domain, human Integrin alpha 2b shares 80% and 78% amino acid sequence identity with mouse and rat Integrin alpha 2b, respectively.

Alternate Names

CD41, GP2B, GPIIb, GTA, HPA3, ITGA2b

Entrez Gene IDs

3674 (Human); 16399 (Mouse); 29350 (Rat); 102119413 (Cynomolgus Monkey)

Gene Symbol

ITGA2B

Additional Integrin alpha 2b/CD41 Products

Product Documents for Human Integrin  alpha 2b/CD41 APC‑conjugated Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human Integrin  alpha 2b/CD41 APC‑conjugated Antibody

For research use only

Citations for Human Integrin  alpha 2b/CD41 APC‑conjugated Antibody

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