Detects human Integrin alpha 2b/CD41 in direct ELISAs.
In direct ELISAs, no cross-reactivity
with recombinant human Integrin alpha 5, alpha 8, alpha V, beta 3, beta 5, beta 6, recombinant mouse Integrin beta 2b or beta 3 is observed.
Monoclonal Mouse IgG1 Clone # 745201
Protein A or G purified from hybridoma culture supernatant
heterodimer of human Integrin alpha 2B (Leu32-Arg993; R887L) Accession P08514 + human Integrin beta 3 (Gly27-Asp718) Accession P05106
Supplied in a saline solution containing BSA and Sodium Azide.
Detection of Integrin alpha 2b/CD41 in Human Blood Platelets by Flow Cytometry.
Human peripheral blood platelets were stained with FITC-conjugated Anti-Human Integrin alpha 2b/CD41 (Clone P2) and either (A) Mouse Anti-Human Integrin alpha 2b/CD41 PE‑conjugated Monoclonal Antibody (Catalog # FAB7616P) or (B) Mouse IgG1 Phycoerythrin Isotype Control (Catalog # IC002P). FAB7616P stains the same population as Clone P2. View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
12 months from date of receipt, 2 to 8 °C as supplied.
Background: Integrin alpha 2b/CD41
Integrin alpha 2b (ITGA2b), also known as CD41 and GPIIb, is a transmembrane glycoprotein that is expressed by megakaryocytes and platelets. It is cleaved into two disulfide-linked chains (114 kDa and 22 kDa) during transit through the Golgi. Integrin alpha 2b associates with Integrin beta 3 to form complexes that interact with Fibrinogen, von Willebrand factor, Fibronectin, and Vitronectin. Integrin alpha 2b is required for platelet aggregation, and defects lead to disorders of coagulation. Within the extracellular domain, human Integrin alpha 2b shares 80% and 78% amino acid sequence identity with mouse and rat Integrin alpha 2b, respectively.
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