Human Integrin  alpha 4 beta 7/LPAM-1 (Research Grade Abrilumab Biosimilar) Antibody

Recombinant Monoclonal Antibody For Research Use Only
Catalog # Availability Size / Price Qty
MAB10548-100
MAB10548-SP
Detection of Integrin alpha 4 beta 7 in Human PBMC by Flow Cytometry.
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Human Integrin  alpha 4 beta 7/LPAM-1 (Research Grade Abrilumab Biosimilar) Antibody Summary

Species Reactivity
Human
Specificity
Detects Human Integrin  alpha 4 beta 7/LPAM‑1 in direct ELISAs.This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Abrilumab. This product is for research use only.
Source
Recombinant Monoclonal Human IgG1 Clone # Hu143
Purification
Protein A or G purified from cell culture supernatant
Immunogen
Human Integrin alpha4 beta7
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Flow Cytometry
0.25 µg/106 cells
Human PBMC
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of Integrin alpha 4 beta 7 antibody in Human PBMC antibody by Flow Cytometry. View Larger

Detection of Integrin alpha 4 beta 7 in Human PBMC by Flow Cytometry. Human PBMC were stained with (A) Human Anti-Human Integrin a4 beta 7 (Research Grade Abrilumab Biosimilar) Monoclonal Antibody (Catalog # MAB10548) or (B) no primary antibody, followed by anti-Human IgG APC-conjugated Secondary Antibody (F0135) and Mouse anti-Human CD3 PE-conjugated Monoclonal Antibody (FAB100P). Staining was performed using our Staining Membrane-associated Proteins protocol.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Integrin alpha 4 beta 7/LPAM-1

Abrilumab is an anti-human alpha 4 beta 7 integrin heterodimer monoclonal antibody designed for the treatment of inflammatory bowel disease, ulcerative colitis, and Crohn's disease.

Entrez Gene IDs
3676 (Human); 16402 (Mouse)
Alternate Names
269C wild type; CD49 antigen-like family member D; CD49d antigen; CD49d; CD49d/beta7; CD49Dantigen CD49D, alpha-4 subunit of VLA-4 receptor; IA4; Integrin alpha 4 beta 7; integrin alpha 4; integrin alpha-4 subunit; integrin alpha-4; Integrin alpha-IV; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); LPAM1; LPAM-1; MGC90518; very late activation protein 4 receptor, alpha 4 subunit; VLA-4 subunit alpha

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