Human Integrin  alpha V/CD51 Alexa Fluor® 488-conjugated Antibody

Catalog # Availability Size / Price Qty
FAB1219G-025
Human Integrin  alpha V/CD51 Alexa Fluor® 488-conjugated Antibody in Data
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Citations (2)
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Human Integrin  alpha V/CD51 Alexa Fluor® 488-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects the ectodomain of human Integrin alpha V/CD51.
Source
Monoclonal Mouse IgG1 Clone # P2W7
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Ocular melanoma cell line
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Alexa Fluor 488 (Excitation= 488 nm, Emission= 515-545 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
5 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Example

Flow Cytometry Detection of Integrin aV/CD51 antibody in HT1080 Human Cell Line antibody by Flow Cytometry. View Larger

Detection of Integrin alpha V/CD51 in HT1080 Human Cell Line by Flow Cytometry. HT1080 human fibrosarcoma cell line was stained with Mouse Anti-Human Integrin aV/CD51 Alexa Fluor® 488-conjugated Monoclonal Antibody (Catalog # FAB1219G, filled histogram) or isotype control antibody (Catalog # IC002G, open histogram). View our protocol for Staining Membrane-associated Proteins.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: Integrin alpha V/CD51

Integrin alpha V (CD51), also known as Vitronectin Receptor subunit alpha, is a 140-150 kDa member of the integrin alpha -chain family of adhesion molecules. It forms disulfide-linked integral membrane heterodimers with at least five beta -chains, including beta 1, 3, 5, 6 and 8. Human  alpha V is a 1018 amino acid (aa) type I transmembrane glycoprotein that contains a 962 aa extracellular domain (ECD) (aa 31-992), and a short 32 aa cytoplasmic tail. The ECD contains seven FG (PheAlaGly)-GAP (GlyAlaPro) repeats that form a beta -propeller domain (aa 46-483). Furin cleavage of the alpha V ECD occurs after Gly889, generating a disulfide-linked heteromeric subunit alpha V chain. alpha V-containing integrins bind multiple ECM molecules, including vitronectin, osteopontin, MMP-2 and TSP. The ECD of human alpha V is 92% aa identical to mouse alpha V ECD.

Entrez Gene IDs
3685 (Human); 16410 (Mouse); 296456 (Rat); 102116249 (Cynomolgus Monkey)
Alternate Names
antigen identified by monoclonal L230; CD51 antigen; CD51; Integrin alpha V; integrin alpha-V; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); ITGAV; MSK8; Vitronectin Receptor alpha; Vitronectin receptor subunit alpha; VNRA; VNRADKFZp686A08142

Product Datasheets

Citations for Human Integrin  alpha V/CD51 Alexa Fluor® 488-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Characterization of the Filovirus-Resistant Cell Line SH-SY5Y Reveals Redundant Role of Cell Surface Entry Factors
    Authors: FJ Zapatero-B, E Dietzel, O Dolnik, K Döhner, R Costa, B Hertel, B Veselkova, J Kirui, A Klintworth, MP Manns, S Pöhlmann, T Pietschman, T Krey, S Ciesek, G Gerold, B Sodeik, S Becker, T von Hahn
    Viruses, 2019;11(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  2. Cytokine Effects on the Entry of Filovirus Envelope Pseudotyped Virus-Like Particles into Primary Human Macrophages
    Authors: TS Stantchev, A Zack-Taylo, N Mattson, K Strebel, CC Broder, KA Clouse
    Viruses, 2019;11(10):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry

FAQs

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