Human Intelectin-2 Alexa Fluor® 594-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Intelectin-2

Intelectin-2 (ITLN-2; also endothelial lectin 2 and HL-2) is a 37-41 kDa, likely Ca-dependent carbohydrate-binding lectin that is a member of the X-lectin family of molecules.  It is secreted by intestinal Paneth cells, and appears to participate in fungal microbe recognition.  The human ITLN-2 precursor is 325 amino acids (aa) in length (SwissProt #:Q8WWU7).  It contains a 26 aa signal sequence and a 299 aa mature region.  Although mouse ITLN-2 is reportedly GPI-linked, and mouse and human ITLN-2 show considerable C-terminal aa identity, it is not known if human ITNL-2 is also GPI-linked.  There is one fibrinogen-related domain in the mature molecule (aa 44-267).  One potential splice variant is reported that shows a premature truncation after Gly264.  Over aa 29-324, human ITLN-2 shares 79% aa sequence identity with mouse ITLN-2/ITLN-1b, and 85% aa sequence identity with human ITLN-1.      

Product Datasheets

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