Human KIR3DL3/CD158z Alexa Fluor® 647-conjugated Antibody Summary
Accession # Q8N743
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of KIR3DL3/CD158z in BaF3 Mouse Cell Line Transfected with KIR3DL3/CD158z by Flow Cytometry. BaF3 mouse pro-B cell line transfected with KIR3DL3/CD158z was stained with Rabbit Anti-Human KIR3DL3/CD158z Alexa Fluor® 647‑conjugated Monoclonal Antibody (Catalog # FAB8919R, filled histogram) or control antibody Rabbit Anti-Human KIR2DS5/CD185g Alexa Fluor® 647‑conjugated Antibody (Catalog # FAB8920R, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
KIR3DL3 is a member of the Killer-Immunoglobulin-like Receptor (KIR) family, a functionally diverse family of transmembrane receptors expressed primarily on NK cells. KIR3DL3 is a “framework” KIR gene, and is present in all individuals, in contrast to non-framework KIRs, whose gene content varies by KIR haplotype. KIR3DL3 is expressed at low or undetectable levels in peripheral blood NK cells, but expression can be induced in NK cell lines by demethylation agents, indicating that promoter DNA methylation inhibits KIR3DL3 transcription. Despite the lack of evidence for surface protein expression, KIR3DL3 mRNA expression has been detected in both decidual and peripheral blood NK cells in normal, disease-free conditions. Over amino acids (aa) 1-322, human KIR3DL3 shares 47% aa sequence identity with mouse KIR3DL1.
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