Human KIR3DL3/CD158z Alexa Fluor® 647-conjugated Antibody

Recombinant Monoclonal Antibody..
  • Species Reactivity
  • Specificity
    Detects human KIR3DL3/CD158z in direct ELISAs.
  • Source
    Recombinant Monoclonal Rabbit IgG Clone # 1136B
  • Purification
    Protein A or G purified from cell culture supernatant
  • Immunogen
    Human embryonic kidney cell line HEK293-derived recombinant human KIR3DL3/CD158z
    Accession # Q8N743
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
    Alexa Fluor 647
  • Flow Cytometry
    5 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
Detection of KIR3DL3/CD158z in BaF3 Mouse Cell Line Transfected with KIR3DL3/CD158z by Flow Cytometry. BaF3 mouse pro-B cell line transfected with KIR3DL3/CD158z was stained with Rabbit Anti-Human KIR3DL3/CD158z Alexa Fluor® 647‑conjugated Monoclonal Antibody (Catalog # FAB8919R, filled histogram) or control antibody Rabbit Anti-Human KIR2DS5/CD185g Alexa Fluor® 647‑conjugated Antibody (Catalog # FAB8920R, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: KIR3DL3/CD158z
KIR3DL3 is a member of the Killer-Immunoglobulin-like Receptor (KIR) family, a functionally diverse family of transmembrane receptors expressed primarily on NK cells. KIR3DL3 is a “framework” KIR gene, and is present in all individuals, in contrast to non-framework KIRs, whose gene content varies by KIR haplotype. KIR3DL3 is expressed at low or undetectable levels in peripheral blood NK cells, but expression can be induced in NK cell lines by demethylation agents, indicating that promoter DNA methylation inhibits KIR3DL3 transcription. Despite the lack of evidence for surface protein expression, KIR3DL3 mRNA expression has been detected in both decidual and peripheral blood NK cells in normal, disease-free conditions. Over amino acids (aa) 1-322, human KIR3DL3 shares 47% aa sequence identity with mouse KIR3DL1.
  • Long Name:
    Killer Cell Immunoglobulin-like Receptor, Three Domain Long Cytoplasmic Tail, 3
  • Entrez Gene IDs:
    115653 (Human)
  • Alternate Names:
    CD158z; KIR3DL7; KIR44; KIRC1
Related Research Areas
Isotype Controls
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Rabbit IgG Alexa Fluor® 647-conjugated Antibody

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