Human LAIR1 PE-conjugated Antibody

(3 citations)   
  • Species Reactivity
  • Specificity
    Detects human LAIR1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human LAIR2 or recombinant mouse LAIR1 is observed.
  • Source
    Monoclonal Mouse IgG2B Clone # 342219
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    Mouse myeloma cell line NS0-derived recombinant human LAIR1 isoform 1
    Accession # Q6GTX8
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
Detection of LAIR1 in Human Lymphocytes by Flow Cytometry. Human lymphocytes were stained with Mouse Anti-Human LAIR1 PE‑conjugated Monoclonal Antibody (Catalog # FAB2664P, filled histogram) or isotype control antibody (Catalog # IC0041P, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: LAIR1
LAIR1 is an inhibitory receptor belonging to the Ig superfamily. It is a type I transmembrane protein with one extracellular Ig-like domain and two cytoplasmic ITIMs. Four LAIR1 splice variants exist. LAIR1b has a 17 aa deletion outside the Ig loop in the extracellular domain. It differs from LAIR1c by one amino acid (aa) residue. LAIR1d has a 77 aa truncation in the cytoplasmic domain. LAIR1 is expressed on NK cells, T cells, B cells, monocytes, dendritic cells and most thymocytes. The extracellular domain of human LAIR1 shares 40% aa sequence identity with that of the mouse ortholog.
  • Long Name:
    Leukocyte-associated Ig-like Receptor 1
  • Entrez Gene IDs:
    3903 (Human)
  • Alternate Names:
    CD305 antigen; CD305; CD305leukocyte-associated Ig-like receptor 1; hLAIR1; LAIR-1; leukocyte-associated immunoglobulin-like receptor 1
Related Research Areas

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

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Sample Type
  1. EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors.
    J. Clin. Invest., 2102;122(4):1487-502.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  2. Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry.
    Authors: Llinas L, Lazaro A, de Salort J, Matesanz-Isabel J, Sintes J, Engel P
    Immunol. Lett., 2011;134(2):113-21.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  3. Differential expression of SLAMS and other modulatory molecules by human plasma cells during normal maturation.
    Authors: Rodriguez-Bayona B, Ramos-Amaya A, Brieva JA
    Immunol. Lett., 2011;134(2):122-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
Isotype Controls
Description Application Cat# Citations Images  

Mouse IgG2B PE-conjugated Antibody

Ctrl IC0041P 12  
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Staining Reagents
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Flow Cytometry Staining Buffer (1X)

Flow FC001 3
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Flow Cytometry Mouse Lyse Buffer (10X)

Flow FC003 1
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Flow Cytometry Human Lyse Buffer (10X)

Flow FC002 1
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