Human/Mouse FGF-23 Antibody

Catalog #: MAB2629
4 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB2629
MAB2629-SP

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Product Details

Citations (4)

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human/Mouse FGF-23 Antibody Summary

Species Reactivity

Human, Mouse

Specificity

Detects human and mouse FGF-23 in direct ELISAs and Western blots. Does not cross-react with recombinant human (rh) FGF acidic, rhFGF basic, rhFGF-3, -4, -5, -6, -7, -9, -10, -11, -12, -13, -16, -17, -18, -19, -20, -21, recombinant mouse (rm) FGF‑8b, rmFGF‑8c, or rmFGF-15.

Source

Monoclonal Rat IgG_2B Clone # 283511

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

Mouse myeloma cell line NS0-derived recombinant mouse FGF-23
Tyr25-Val251 (Arg179Gln)
Accession # Q9EPC2

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration

Sample

Western Blot

1 µg/mL

Recombinant Human FGF‑23 (Catalog # 2604-FG)
Recombinant Mouse FGF‑23 (Catalog # 2629-FG)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Reconstitution Buffer Available

Reconstitution Buffer 1 (PBS)

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: FGF-23

FGF-23 is a secreted protein primarily expressed in the brain and thymus. Mutations in FGF-23 produced by osteomalacia tumors are linked to autosomal dominant hypophosphatemic rickets and several bone structure disorders.

Long Name

Fibroblast Growth Factor 23

Entrez Gene IDs

8074 (Human); 64654 (Mouse)

Alternate Names

ADHR; FGF23; FGF-23; fibroblast growth factor 23; HPDR2; HYPF; phosphatonin; PHPTC; tumor-derived hypophosphatemia inducing factor; Tumor-derived hypophosphatemia-inducing factor

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citations for Human/Mouse FGF-23 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

4 Citations: Showing 1 - 4
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Twist1-Haploinsufficiency Selectively Enhances the Osteoskeletal Capacity of Mesoderm-Derived Parietal Bone Through Downregulation of Fgf23
Authors: N Quarto, S Shailendra, NP Meyer, S Menon, A Renda, MT Longaker
Front Physiol, 2018-10-15;9(0):1426.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot
FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts
Authors: ER Smith, SJ Tan, SG Holt, TD Hewitson
Sci Rep, 2017-06-13;7(1):3345.
Species: Mouse
Sample Types: Tissue Homogenates, Whole Tissue
Applications: IHC, Western Blot
Osteocyte-specific deletion of Fgfr1 suppresses FGF23.
Authors: Xiao Z, Huang J, Cao L, Liang Y, Han X, Quarles L
PLoS ONE, 2014-08-04;9(8):e104154.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot
Fibroblast growth factor 23 concentrations in healthy term infants during the early postpartum period.
Authors: Takaiwa M, Aya K, Miyai T
Bone, 2010-08-01;47(2):256-62.
Species: Human
Sample Types: Plasma
Applications: Western Blot