Human/Mouse FoxO3 Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: FoxO3

Forkhead box O3 (FoxO3) is a ubiquitously expressed 72 kDa transcriptional regulator that is involved in cellular differentiation, angiogenesis, tumor progression, apoptosis, and the responses to oxidative stress and DNA damage. Phosphorylation of FoxO3 by Akt induces its association with 14-3-3 proteins and its retention in the cytoplasm. In response to the loss of survival factors, dephosphorylation of FoxO3 induces its translocation to the nucleus where it promotes apoptosis. Its level of acetylation is regulated in response to cellular metabolic requirements. Within amino acids 372‑673 (C-terminal to the DNA binding domain), human FoxO3 shares 95% aa sequence identity with mouse and rat FoxO3.

Product Datasheets

Related Research Areas

• Apoptosis Transcription Factors and Regulators
• Cancer Biomarkers
• Cancer Stem Cell Transcription Factors
• Checkpoint
• Forkhead Domain Transcription Factors
• Hematopoietic Stem Cell Transcription Factors and Regulators
• Infectious Diseases
• Neural Stem Cell Transcription Factors
• Transcription Factors in the Akt Pathway
• Transcription Regulators in VSMC