Common Cytokine Receptor Gamma-Chain Family Signaling Pathways

Click on one of the common cytokine receptor gamma-chain family members below to see the cytokine-specific receptor, receptor-expressing cells, and the signaling pathways activated by each cytokine.

Cytokine-specific receptor subunit
Cytokine-specific receptor subunit
Common gamma chain
Common gamma chain
ProductsClose
Jak1
Jak1
ProductsClose
ProductsClose
Jak3
Jak3
ProductsClose
STAT
STAT
STAT Dimer
STAT Dimer
PI 3-K
PI 3-K
ProductsClose
PDK-1
PDK-1
ProductsClose
Akt/PKB
Akt/PKB
p70 S6K
p70 S6K
ProductsClose
Bad
Bad
ProductsClose
GSK-3
GSK-3
Forkhead
Forkhead
ProductsClose
IRS
IRS
ProductsClose
ProductsClose
Shc
Shc
ProductsClose
ProductsClose
GRB2
GRB2
ProductsClose
ProductsClose
SOS
SOS
ProductsClose
ProductsClose
Ras
Ras
ProductsClose
Raf
Raf
MEK1/2
MEK1/2
ERK1/2
ERK1/2
ProductsClose
We currently do not offer products for this molecule

Use our Product Suggestion form to enter a request.

You will be notified once it becomes available.
PIP2
PIP2
ProductsClose
We currently do not offer products for this molecule

Use our Product Suggestion form to enter a request.

You will be notified once it becomes available.
ProductsClose
PIP3
PIP3
ProductsClose

Anti-Apoptotic

Anti-Apoptotic

Mitogenic

Mitogenic

Target Genes
Target Genes

Overview of Common Cytokine Receptor gamma-Chain Family Cytokines

Cytokines belonging to the common cytokine receptor gamma chain family include IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Members of this family signal through receptor complexes that contain the common gamma chain subunit. This subunit associates with different cytokine-specific receptor subunits to form unique heterodimeric receptors for IL-4, IL-7, IL-9, and IL-21, or associates with both IL-2/IL-15 R beta and IL-2 R alpha or IL-15 R alpha to form heterotrimeric receptors for IL-2 or IL-15, respectively. Common gamma chain family cytokines generally activate three major signaling pathways that promote cellular survival and proliferation, the PI 3-K-Akt pathway, the RAS-MAPK pathway, and the JAK-STAT pathway.

/p>Common gamma chain family cytokines serve as critical regulators of the development, survival, proliferation, differentiation and/or function of multiple immune cell types. These cytokines can have both unique and overlapping effects on different cell types, depending primarily on the expression patterns of the cytokines and their unique receptor subunits, and the activation of different STAT proteins. Inactivating mutations in the common gamma chain family cytokines, their receptors, or a subset of intracellular signaling molecules involved in these pathways can lead to severe immune system defects. The most common form of severe combined immunodeficiency, X-linked SCID, is caused by mutations in the common cytokine receptor gamma chain subunit.

To learn more, please visit our Common gamma Chain Receptor Family Research Area.