Human/Mouse R‑Spondin 1 Alexa Fluor™ Plus 594‑conjugated Antibody

Name: Human/Mouse R‑Spondin 1 Alexa Fluor™ Plus 594‑conjugated Antibody
Brand: R&D Systems
SKU: FAB4658AFP594
Price: 569 USD
Availability: InStock

R&D Systems | Catalog # FAB4658AFP594

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Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot

Label

Alexa Fluor Plus 594 (Excitation = 590 nm, Emission = 618 nm)

Antibody Source

Monoclonal Mouse IgG_2B Clone # 422407

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Product Specifications

Specificity

Detects human and mouse R-Spondin 1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody does not cross-react with recombinant human (rh) R-Spondin 2 or rhR-Spondin 3.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG_2B

Applications for Human/Mouse R‑Spondin 1 Alexa Fluor™ Plus 594‑conjugated Antibody

Application

Recommended Usage

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: R-Spondin 1

RSPO-1 (roof plate-specific spondin; also R-spondin1 and cristin3) is a 39 kDa, heparin-binding member of the Cristin/R-spondin family of proteins. These molecules apparently are either retained intracellularly or secreted, where they activate the frizzled-LRP receptor pathway. Mature human RSPO-1 is 27 kDa and 243 amino acids (aa) in length. It contains a cysteine-rich furin repeat domain followed by a type I TSP domain. This form is apparently retained intracellularly. A presumably glycosylated, 30 kDa, 193 aa C-terminally truncated form is secreted and interacts with heparin. The secreted form of human RSPO-1 is 93% aa identical to secreted mouse RSPO-1.

Long Name

Roof Plate-specific Spondin 1

Alternate Names

Cristin 3, CRISTIN3, HRspo1, RSPO, RSPO1, RSpondin 1

Entrez Gene IDs

284654 (Human); 192199 (Mouse); 102122369 (Cynomolgus Monkey)

Gene Symbol

RSPO1

UniProt

NP_775911

Additional R-Spondin 1 Products

Product Documents for Human/Mouse R‑Spondin 1 Alexa Fluor™ Plus 594‑conjugated Antibody

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Certificate of Analysis

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Product Specific Notices for Human/Mouse R‑Spondin 1 Alexa Fluor™ Plus 594‑conjugated Antibody

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only