Home / Bax / Human/Mouse/Rat Bax aa 12-24 Antibody

Human/Mouse/Rat Bax aa 12-24 Antibody

Catalog #: 2281-MC
6 Citations Datasheet / COA / SDS

Discontinued Product

2281-MC has been discontinued.
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Product Details
Citations (6)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human/Mouse/Rat Bax aa 12-24 Antibody Summary

Species Reactivity
Human, Mouse, Rat
Specificity
Anti-Bax (Clone YTH-6A7) cross reacts with human, mouse and rat Bax.
Source
Monoclonal Mouse IgG1 Clone # YTH-6A7
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Human Bax
aa 12-24
Formulation
This antibody is provided as purified immunoglobulin from mouse ascites in 1X PBS containing 0.01% sodium azide.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1:1000 dilution
Immunoprecipitation
Please refer to the PDF datasheet for specifications.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4 °C.

Background: Bax

The Bcl-2 family of proteins plays a crucial role in the regulation of cell death in many eukaryotic systems. Bax has been shown to redistribute from the cytosol to the mitochondria during apoptosis, and over-expression of Bax can accelerate cell death. Coregulation of Bax dimer formation and intracellular localization are associated with Bax conformational changes.

Long Name
Bcl Associated X Protein
Entrez Gene IDs
581 (Human); 12028 (Mouse); 24887 (Rat)
Alternate Names
apoptosis regulator BAX; Bax; BCL2-associated X protein; Bcl2-L-4; BCL2L4bcl2-L-4; Bcl-2-like protein 4

Product Datasheets

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COA
SDS

Product Specific Notices

  1. Suzuki, M. et al. 2000, Cell 103:645-54.
  2. Hsu, Y.-T. et al. 1997, Proc. Natl. Acad. Sci. USA 94:3668-3672.
  3. Hsu, Y.-T. and R.J. Youle. 1997, J. Biol. Chem. 272:13829-13834.
  4. Neuchushtan, A. et al. 1999, EMBO J.18:2330-2341.

Citations for Human/Mouse/Rat Bax aa 12-24 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
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  1. Super-resolution microscopy reveals that Na+/K+-ATPase signaling protects against glucose-induced apoptosis by deactivating Bad
    Authors: K Bernhem, JM Fontana, D Svensson, L Zhang, LM Nilsson, L Scott, H Blom, H Brismar, A Aperia
    Cell Death & Disease, 2021-07-27;12(8):739.
    Species: Rat
    Sample Types: Whole Cells
    Applications: IHC
  2. FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM
    Authors: D Watanabe, A Nogami, K Okada, H Akiyama, Y Umezawa, O Miura
    Cancers (Basel), 2019-11-20;11(12):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  3. The vaccinia virus-encoded Bcl-2 homologues do not act as direct Bax inhibitors.
    Authors: Postigo A, Way M
    J Virol, 2011-10-19;86(1):203-13.
  4. RASSF1A and the BH3-only mimetic ABT-737 promote apoptosis in pediatric medulloblastoma cell lines.
    Authors: Levesley J, Lusher M, Lindsey J, Clifford S, Grundy R, Coyle B
    Neuro Oncol, 2011-08-31;13(12):1265-76.
  5. Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells.
    Authors: Kojima K, Konopleva M, Samudio IJ
    Cancer Res., 2007-04-01;67(7):3210-9.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: Flow Cytometry, Western Blot
  6. Cyclin-dependent kinase inhibitor Roscovitine induces apoptosis in chronic lymphocytic leukemia cells.
    Authors: Hahntow IN, Schneller F, Oelsner M
    Leukemia, 2004-04-01;18(4):747-55.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot

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