Human/Mouse/Rat Complexin-2 Alexa Fluor® 647-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Complexin-2

Complexin-2 (CPX II; also known as synaphin-1) is a 19 kDa, cytosolic protein that belongs to the complexin/synaphin family of molecules. It is expressed in excitatory neurons and serves as a block against premature granule release by its binding to the cis-SNARE complex that contains SNAP25, VAMP2 and STX1A. Human Complexin-2 is 134 amino acids (aa) in length and contains one coiled-coil domain (aa 28‑84) that incorporates part of a SNARE complex interaction sequence (aa 41‑97). There is one potential splice variant that shows a premature truncation after Glu114. Human Complexin-2 is identical in aa sequence to that for mouse and rat Complexin-2.

Product Datasheets

Related Research Areas

• Synaptic Proteins
• Synaptic SNAREs