Human/Mouse/Rat Vang-like Protein 2/VANGL2 Alexa Fluor® 750-conjugated Antibody

Catalog #: AF4815S Datasheet / COA / SDS

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AF4815S-100UG

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All Vang-like Protein 2/VANGL2 Antibodies

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Human/Mouse/Rat Vang-like Protein 2/VANGL2 Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat

Specificity

Detects human, mouse, and rat Vang-like Protein 2/VANGL2 in direct ELISAs and Western blots. In direct ELISAs, approximately 10% cross-reactivity with recombinant human VANGL1 is observed.

Source

Polyclonal Sheep IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant human Vang-like Protein 2/VANGL2
Gln241-Val521
Accession # Q9ULK5

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Vang-like Protein 2/VANGL2

VANGL2 (van Gogh-like protein 2; also Strabismus and Ltap) is a 65 kDa member of the Vang family of proteins. It is found in the membranes of embryonic neurons and epithelium where it associates with DVL1-3 and various frizzleds. VANGL2 mutations are associated with neural tube defects. Human VANGL2 is a 521 amino acid (aa) 4-transmembrane protein that contains an N-terminal (aa 1‑108) and C-terminal (aa 239‑521) cytoplasmic domain. There is a Ser-rich region in the N-terminus (aa 5‑20) and a PDZ-binding motif over aa 506‑521. Over aa 241‑521, human, mouse and rat show total identity in amino acid sequence.

Entrez Gene IDs

57216 (Human); 93840 (Mouse); 289229 (Rat)

Alternate Names

KIAA1215Loop-tail protein 1 homolog; loop-tail-associated protein; LPP1; LTAP; LTAPVan Gogh-like protein 2; MGC119403; MGC119404; STB1; STB1Strabismus 1; STBM; STBM1; Strabismus; vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila); Vang like Protein 2; VANGL2; vang-like 2 (van gogh, Drosophila); Vang-like Protein 2