Human/Mouse RIPK4/RIP4 Alexa Fluor® 647-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: RIPK4/RIP4

Receptor-interacting serine-threonine kinase 4 (RIPK4/PKK) is a serine/threonine protein kinase which interacts with protein kinase C-delta, but also activates NFkappaB, and interacts with the Wnt3a coreceptor LRP6 after Wnt3a stimulation. RIPK4 is required for keratinocyte differentiation and has broad expression in epithelial tissues. Down regulation of RIPK4 has been observed in squamous cell carcinomas, hepatocellular carcinoma, urothelial carcinoma and cervical carcinoma. Mutations in in the RIPK4 gene cause Popliteal pterygium syndrome, lethal type (PPS-L), CHAND syndrome and Bartsocas-Papas syndrome.   

Product Datasheets

Related Research Areas

• Apoptosis Adaptor Proteins
• Immunoglobulin-Like Domain Transcription Factors
• Intracellular Kinases in the Akt Pathway
• NFkB Pathway
• TNF Superfamily Regulators