Human/Mouse SALL4 Alexa Fluor® 350-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: SALL4

SALL4 (SAL-like protein 4) is a 1324 amino acid (aa) member of the SAL protein family that possess multiple C₂H₂-type zinc-fingers. It is a transcriptional repressor when associated with histone deacetylase and a transcriptional activator of the Wnt pathway in its native form. It contributes to generation of induced pluripotent stem cells and to axis formation during development. It is frequently overexpressed in germ cell tumors and acute myeloid leukemias. Mutations of human SALL4 can result in conditions such as Okihiro, Duane Radial Ray, or Holt-Oram syndromes. The region used as an immunogen is common to both SALL4 and the ubiquitous 617 aa isoform, SALL4B; it shares 76% aa identity between human and mouse.

Product Datasheets

Related Research Areas

• Cancer Stem Cell Transcription Factors
• Early Endodermal Lineage Markers
• Hematopoietic Stem Cell Transcription Factors and Regulators
• Pluripotent Stem Cell Transcription Factors
• Primitive Endoderm Markers
• Transcription Factors and Regulators
• Wnt Signaling Modulators